Home > Name List By other > (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15, 16-oc...

CAS No 67452-97-5 , (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one

  • Name: (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Synonyms: (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one; SureCN4127; 67452-97-5; 7alpha-Chloro-16alpha-methylprednisolone; CHEBI:53776; Alclomethasone;Aclometasone; CHEMBL1201361;
  • CAS Registry Number:
  • Flash Point: 320.9°C
  • Boiling Point: 607.1°Cat760mmHg
  • Density: 1.34g/cm3
  • Refractive index: 1.607
  • Flash Point: 320.9°C
  • Molecular Weight: 408.91566
  • InchiKey: FJXOGVLKCZQRDN-PHCHRAKRSA-N
  • InChI: InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,
    2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,
    26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1
  • Molecular Formula: C22H29ClO5
  • Molecular Structure:CAS No:67452-97-5 (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,<br />17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,<br />16-octahydro-6H-cyclopenta[a]phenanthren-3-one

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67452-97-5 Alclometasone

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67452-97-5 ALCLOMETASONE

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67452-97-5 Pregna-1,4-diene-3,20-dione,7-chloro-11,17,21-trihydroxy-16-methyl-, (7a,11b,16a)-

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67452-97-5 ALCLOMETASONE

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References of (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-chloro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Title: Alclometasone
CAS Registry Number: 67452-97-5
CAS Name: (7a,11b,16a)-7-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 7a-chloro-16a-methylprednisolone
Molecular Formula: C22H29ClO5
Molecular Weight: 408.92
Percent Composition: C 64.62%, H 7.15%, Cl 8.67%, O 19.56%
Literature References: Non-fluorinated corticosteroid with low systemic effects. Prepn: M. J. Green et al., US 4076708; M. J. Green, H. J. Shue, US 4124707 (both 1978 to Schering); M. J. Green et al., J. Steroid Biochem. 11, 61 (1979); H. J. Shue et al., J. Med. Chem. 23, 430 (1980). Topical anti-inflammatory activity of the 17,21-dipropionate: B. Lutsky et al., Arzneim.-Forsch. 29, 992 (1979); M. J. Green et al., ibid. 30, 1618 (1980).
Properties: Crystals from acetone/hexane, mp 176-179°. [a]D26 +47.5° (c = 0.3 in DMF). uv max (methanol): 242 nm (e 15500).
Melting point: mp 176-179°
Optical Rotation: [a]D26 +47.5° (c = 0.3 in DMF)
Absorption maximum: uv max (methanol): 242 nm (e 15500)
 
Derivative Type: 17,21-Dipropionate
CAS Registry Number: 66734-13-2
Manufacturers' Codes: Sch-22219
Trademarks: Aclosone (Schering); Aclovate (GSK); Almeta (Shionogi); Delonal (Essex); Legederm (Schering); Modrasone (Schering); Perderm (Schering)
Molecular Formula: C28H37ClO7
Molecular Weight: 521.04
Percent Composition: C 64.54%, H 7.16%, Cl 6.80%, O 21.49%
Properties: Crystals from acetone/methanol/isopropyl ether, mp 212-216°. [a]D26 +42.6° (c = 0.3 in DMF). uv max (methanol): 242 nm (e 15600).
Melting point: mp 212-216°
Optical Rotation: [a]D26 +42.6° (c = 0.3 in DMF)
Absorption maximum: uv max (methanol): 242 nm (e 15600)
 
Therap-Cat: Anti-inflammatory (topical).
Keywords: Glucocorticoid.