Home > Name List By other > (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6, 9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12, 14,15,16,17-oc...

CAS No 2607-06-9 , (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,
9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,
14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one

  • Name: (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,
    9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,
    14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Synonyms: 2607-06-9;(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,
    9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,
    14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one; Diflucortolonum; Diflucortolona; Diflucortolone [USAN:INN:BAN]; Diflucortolonum [INN-Latin]; Diflucortolona [INN-Spanish];
  • CAS Registry Number:
  • Melting Point: 220ºC
  • Density: 1.29 g/cm3
  • Refractive index: 1.562
  • EINECS: 220-022-6
  • Molecular Weight: 394.452126
  • InchiKey: OGPWIDANBSLJPC-RFPWEZLHSA-N
  • InChI: InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,
    24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,
    8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
  • Molecular Formula: C22H28F2O4
  • Molecular Structure:CAS No:2607-06-9 (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,<br />9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,<br />14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one

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References of (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,
9-difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,
14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
Title: Diflucortolone
CAS Registry Number: 2607-06-9
CAS Name: (6a, 11b, 16a)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 6a,9a-difluoro-16a-methyl-1,4-pregnadiene-11b,21-diol-3,20-dione; 6a,9a-difluoro-16a-methyl-1-dehydrocorticosterone
Molecular Formula: C22H28F2O4
Molecular Weight: 394.45
Percent Composition: C 66.99%, H 7.15%, F 9.63%, O 16.22%
Literature References: The 9a-fluoro deriv of fluocortolone, q.v. Prepn: BE 639708; K. Kieslich et al., US 3426128 (1964, 1969, both to Schering AG); eidem, Arzneim.-Forsch. 26, 1462 (1976). Toxicity: P. Gunzel et al., ibid. 1476. Series of articles on pharmacology, toxicity, metabolism and clinical studies: ibid. 26, 1463-1513 (1976).
Properties: Crystals from ethyl acetate-ether, mp 240-244°. uv max: 237 nm (e 16600) (Kieslich, 1969). Also reported as mp 248-249°. [a]D22 +111° (methanol) (Kieslich, 1976).
Melting point: mp 240-244°; mp 248-249°
Optical Rotation: [a]D22 +111° (methanol) (Kieslich, 1976)
Absorption maximum: uv max: 237 nm (e 16600) (Kieslich, 1969)
 
Derivative Type: 21-Valerate
CAS Registry Number: 59198-70-8
Trademarks: Neribas (Schering AG); Neriforte (Schering AG); Nerisona (Schering AG); Nerisone (Schering AG); Temetex (Sauter); Texmeten (Roche)
Molecular Formula: C27H36F2O5
Molecular Weight: 478.57
Percent Composition: C 67.76%, H 7.58%, F 7.94%, O 16.72%
Properties: Crystals, mp 195-195.5°. [a]D22 +100.8° (dioxane). Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel).
Melting point: mp 195-195.5°
Optical Rotation: [a]D22 +100.8° (dioxane)
Toxicity data: Approx LD50 in mice, rats: >4, 3.1 g/kg orally; 180, 13 mg/kg s.c.; 450, 98 mg/kg i.p. (Gunzel).
 
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.