Home > Name List By other > (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12...

CAS No 50629-82-8 , (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-3-one

  • Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-3-one; Sicorten; SMR000466330; SureCN4872; Halometasone (INN);HALOMETASONE MONOHYDRATE; 50629-82-8; 2-Chloroflumethasone; Halomethasone;
  • CAS Registry Number:
  • Flash Point: 316.994°C
  • Boiling Point: 600.538°C at 760 mmHg
  • Density: 1.42 g/cm3 (20 C)
  • Refractive index: 1.586
  • Flash Point: 316.994°C
  • EINECS: 256-664-9
  • Molecular Weight: 444.896586
  • InchiKey: GGXMRPUKBWXVHE-MIHLVHIWSA-N
  • InChI: InChI=1S/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,
    2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,
    30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1
  • Molecular Formula: C22H27ClF2O5
  • Molecular Structure:CAS No:50629-82-8 (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,<br />17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,<br />16-octahydrocyclopenta[a]phenanthren-3-one

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References of (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-3-one
Title: Halometasone
CAS Registry Number: 50629-82-8
CAS Name: (6a,11b,16a)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 2-chloroflumethasone
Manufacturers' Codes: C-48401-Ba
Molecular Formula: C22H27ClF2O5
Molecular Weight: 444.90
Percent Composition: C 59.39%, H 6.12%, Cl 7.97%, F 8.54%, O 17.98%
Literature References: Synthetic corticosteroid. Prepn: G. G. Anner et al., NL 540244; eidem, US 3652554; eidem, CH 551399, C.A. 81, 120864d (1974) (1968, 1972, 1974 all to Ciba-Geigy). Series of clinical trials in eczema, psoriasis, dermatomycoses, bacterial infections: J. Int. Med. Res. 11, Suppl. 1 (1983).
Properties: mp 220-222° (dec).
Melting point: mp 220-222° (dec)
 
Derivative Type: Monohydrate
Trademarks: Sicorten (Novartis)
Molecular Formula: C22H27ClF2O5.H2O
Molecular Weight: 462.91
Percent Composition: C 57.08%, H 6.31%, Cl 7.66%, F 8.21%, O 20.74%
 
Therap-Cat: Anti-inflammatory (topical); antipruritic.
Keywords: Antipruritic; Glucocorticoid.