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SCH900776

    Detailed Description

    SCH900776SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM).

    IC50 Value: 3 nM(Chk1)

    Target: Chk1

    in vitro: SCH 900776 is a less potent inhibitor of Chk2 and CDK2 with IC50 of 1.5 μM and 0.16 μM, respectively.

    Target:Pyruvate dehydrogenase

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