References of (6S,8S,9R,10S,11S,13S,14S,16R,17R)-2-chloro-6,9-difluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-3-one
Title: Halometasone
CAS Registry Number: 50629-82-8
CAS Name: (6a,11b,16a)-2-Chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 2-chloroflumethasone
Manufacturers' Codes: C-48401-Ba
Molecular Formula: C22H27ClF2O5
Molecular Weight: 444.90
Percent Composition: C 59.39%, H 6.12%, Cl 7.97%, F 8.54%, O 17.98%
Literature References: Synthetic corticosteroid. Prepn: G. G. Anner
et al., NL 540244;
eidem, US 3652554;
eidem, CH 551399,
C.A. 81, 120864d (1974) (1968, 1972, 1974 all to Ciba-Geigy). Series of clinical trials in eczema, psoriasis, dermatomycoses, bacterial infections:
J. Int. Med. Res. 11, Suppl. 1 (1983).
Properties: mp 220-222° (dec).
Melting point: mp 220-222° (dec)
Derivative Type: Monohydrate
Trademarks: Sicorten (Novartis)
Molecular Formula: C22H27ClF2O5.H2O
Molecular Weight: 462.91
Percent Composition: C 57.08%, H 6.31%, Cl 7.66%, F 8.21%, O 20.74%
Therap-Cat: Anti-inflammatory (topical); antipruritic.
Keywords: Antipruritic; Glucocorticoid.