GDC-0810 (Brilanestrant, ARN-810, RG6046) is a selective estrogen receptor degrader (SERD) that is designed to bind to the estrogen receptor to limit its function. In addition, when SERDs bind to the estrogen receptor, they may be able to change the shape of the receptor in such a way that the cell eliminates it by degradation.
Description: IU1 is a reversible and specific inhibitor of proteasome-associating Usp14. It does not inhibit other deubiquitinating enzymes of the 26S proteasome. It partially inhibits the ubiquitin chain trimming activity of the 26S proteasome, which could funct...