GDC-0032GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.
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Description: GDC-0994 GDC-0994 is highly selective for ERK1 and ERK2, with biochemical potency of 1.1 nM and 0.3 nM, respectively. IC50 value: 1.1 nM/0.3 nM(ERK1/ERK2) [1] Target: ERK1/ERK2 inhibitor Daily, oral dosing of GDC-0994 results in significant single-ag...
Description: GDC-0152 GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively. IC50 value: 28/14/17/43 nM(Ki, XIAP/ML-IAP/cIAP...