Tinidazole
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Molecular Structure
Detailed Description
Tinidazole
Synonyms:1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol;1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole;bioshik;ethyl(2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
CAS: 19387-91-8
MF: C8H13N3O4S
MW: 247.27
EINECS: 243-014-4
Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Chemical Properties:white solid
Assay:99%
Usage:anti-ulcerative.For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients. Also for the treatment of giardiasis caused by G. duodenalis in both adults and pediatric patients older than three years of age and for the treatment of intestin.
Packing:25kg/paper barrel
ITEMS SPECIFICATIONS RESULTS
Characters White or pale yellow crystalline powder Pale yellow Crystalline powder
Solubility Practically insoluble in water , soluble in acetone and in methylene chloride, springly soluble in methanol. Conforms
Melting range 125 to 128℃ 126℃
Identification A. UV absorption B. IR absorption C. TLC retention time D. Chemical reaction A. Max at 310nm B. Matches with standard C. Matches with standard D. Primary aromatic amines reaction Conforms
Appearance of solution 5.0%(g/ml) solution in acetone should be clear and not more intensely coloured than reference solution Y5 Conforms
Loss on drying NMT 0.5% 0.04%
Sulphated ash NMT 0.1% 0.04%
Heavy metals NMT 20ppm Conforms
Related compounds TLC Impurity A:NMT 0.5% Impurity B:NMT 0.5% Any other unidentified impurity :NMT0.5% Unidentified impurity with more than 0.2%:at most one HPLC Impurity A:NMT 0.5% Impurity B:NMT 0.5% Any other unidentified impurity :NMT0.5% Total impurities :NMT 1.0% Conforms
Organic Volatile Impurity Ethanol :NMT 1000ppm O-xylene:NMT 195.3ppm Conforms
Assay NLT 98.0% NMT 101.0% 99.9%
Conclusion The product complies with the specification of EP5/BP2005 standard.
- Tinidazole
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