Trametinib

• Product NameTrametinib
  CAS No.871700-17-3
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

TrametinibTrametinib (GSK1120212; JTP 74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

IC50 value: 0.92 nM/1.8 nM (MEK1/2) [1]

Target: MEK1/2

in vitro: GSK1120212 inhibits the phosphorylation of MBP regardless of the isotype of Raf and MEK, with IC50 ranging from 0.92 nM to 3.4 nM.

Target:Checkpoint Kinase(Chk)

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