INT-747

• Product NameINT-747
  CAS No.459789-99-2
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

INT-747INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity.

IC50 value: 99 nM(EC50) [1]

Target: FXR agonist

in vitro: The exposure of rat hepatocytes to 1 microM 6-ECDCA caused a 3- to 5-fold induction of small heterodimer partner (Shp) and bile salt export pump (bsep) mRNA and 70 to 80% reduction of cholesterol 7alpha-hydroxylase (cyp7a1), oxysterol 12beta-hydroxylase (cyp8b1), and Na(+)/taurocholate cotransporting peptide (ntcp) [2].

in vivo: In vivo administration of 6-ECDCA protects against cholestasis induced by E(2)17alpha [2].

Target:Aurora Kinase

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