BYL-719

• Product NameBYL-719
  CAS No.1217486-61-7
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

BYL-719BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, ;liitle or no effect on PI3Kβ/γ/δ.

IC50 value: 5 nM [1]

Target: PI3Kα

in vitro: BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway [1].

in vivo: BYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents.

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