Home > Name List By 3 > 3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 75530-68-6 , 3-O-methyl 5-O-propan-2-yl
2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 3-O-methyl 5-O-propan-2-yl
    2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: Nivadil; Nilvadipinum [Latin]; Nivadipine; FR-34235; FR 34235; Nilvadipino [Spanish];Escor; 75530-68-6;3-O-methyl 5-O-propan-2-yl
    2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;
  • CAS Registry Number:
  • Flash Point: 272.3 ºC
  • Boiling Point: 526.7 ºC at 760 mmHg
  • Density: 1.32 g/cm3
  • Refractive index: 1.568
  • Safety Statements: Moderately toxic by ingestion and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 272.3 ºC
  • Molecular Weight: 385.37066
  • InchiKey: FAIIFDPAEUKBEP-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16
    (15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
  • Molecular Formula: C19H19N3O6
  • Molecular Structure:CAS No:75530-68-6 3-O-methyl 5-O-propan-2-yl<br />2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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75530-68-6 nilvadipine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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75530-68-6 nilvadipine

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75530-68-6 nilvadipine

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
  • Fax: +86-571-85420103
  • Address: 607, North Zhongshan Road, Hangzhou 310000 China ,ZhejiangChina
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75530-68-6 Nilvadipine

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75530-68-6 NILVADIPINE

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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75530-68-6 NILVADIPINE

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA ,China
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75530-68-6 Nilvadipine

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75530-68-6 NILVADIPINE

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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References of 3-O-methyl 5-O-propan-2-yl
2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Nilvadipine
CAS Registry Number: 75530-68-6
CAS Name: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
Synonyms: 5-isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; nivadipine; nivaldipine
Manufacturers' Codes: FR-34235; FK-235; SKF-102362
Trademarks: Escor (Merck KGaA); Nivadil (Fujisawa)
Molecular Formula: C19H19N3O6
Molecular Weight: 385.37
Percent Composition: C 59.22%, H 4.97%, N 10.90%, O 24.91%
Literature References: Dihydropyridine calcium channel blocker. Prepn: Y. Sato, BE 879263; idem, US 4338322 (1980, 1982 both to Fujisawa). Structural studies: A. Miyamae et al., Chem. Pharm. Bull. 34, 3071 (1986). Determn in plasma and urine: Y. Tokuma et al., J. Chromatogr. 415, 156 (1987). Preliminary pharmacokinetics and resolution of enantiomers: eidem, J. Pharm. Sci. 76, 310 (1987). Pharmacokinetics in rabbits: Y. Nezasa et al., Kankyo Igaku Kenkyusho Nenpo 38, 200 (1987), C.A. 107, 89273q (1987). Mode of action: P. A. Molyvdas, N. Sperelakis, J. Cardiovasc. Pharmacol. 8, 449 (1986). Cardiovascular effects: G. J. Gross et al., Gen. Pharmacol. 14, 677 (1983). Clinical evaluation in hypertension: K. Mizuno et al., Res. Commun. Chem. Pathol. Pharmacol. 52, 3 (1986).
Properties: Yellow prisms from ethanol, mp 148-150°.
Melting point: mp 148-150°
 
Derivative Type: (+)-Form
Properties: [a]D20 +222.42° (c = 1 in methanol).
Optical Rotation: [a]D20 +222.42° (c = 1 in methanol)
 
Derivative Type: (-)-Form
Properties: [a]D20 -219.62° (c = 1 in methanol).
Optical Rotation: [a]D20 -219.62° (c = 1 in methanol)
 
Therap-Cat: Antihypertensive; antianginal.
Keywords: Antianginal; Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.