Home > Name List By 3 > 3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 66085-59-4 , 3-O-(2-methoxyethyl) 5-O-propan-2-yl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 3-O-(2-methoxyethyl) 5-O-propan-2-yl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: 66085-59-4;Nimotop; Nimodipino; Periplum;3-O-(2-methoxyethyl) 5-O-propan-2-yl
    2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Admon; Nimodipinum; Nimodipinum [INN-Latin]; Nimodipino [INN-Spanish];
  • CAS Registry Number:
  • Melting Point: 125 ºC
  • Flash Point: 277.3 ºC
  • Boiling Point: 534.8 ºC at 760 mmHg
  • Density: 1.212g/cm3
  • Refractive index: 1.561
  • Water Solubility: Insoluble
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 277.3 ºC
  • EINECS: 266-127-0
  • Molecular Weight: 418.44034
  • InchiKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-
    28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
  • Risk Statements: S36
  • Molecular Formula: C21H26N2O7
  • Molecular Structure:CAS No:66085-59-4 3-O-(2-methoxyethyl) 5-O-propan-2-yl<br />2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 3-O-(2-methoxyethyl) 5-O-propan-2-yl
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Nimodipine
CAS Registry Number: 66085-59-4
CAS Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
Synonyms: 2-methoxyethyl 1,4-dihydro-5-(isopropoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate; isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate; 2,6-dimethyl-4-(3￠-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-b-methoxyethyl ester 5-isopropyl ester
Manufacturers' Codes: Bay e 9736
Trademarks: Admon (Esteve); Nimotop (Bayer); Periplum (Italfarmaco)
Molecular Formula: C21H26N2O7
Molecular Weight: 418.44
Percent Composition: C 60.28%, H 6.26%, N 6.69%, O 26.77%
Literature References: Dihydropyridine calcium channel blocker. Prepn: H. Meyer et al., DE 2117571; eidem, US 3799934 (1972, 1974 to Bayer). Pharmacology: R. Towart, S. Kazda, Br. J. Pharmacol. 67, 409P (1979); K. Tanaka et al., Arzneim.-Forsch. 30, 1494 (1980); L. M. Auer, ibid. 31, 1423 (1981). Prepn of isomers and pharmacological comparison with racemate: R. Towart et al., ibid. 32, 338 (1982). Use as cerebral vasodilator: H. Meyer et al., GB 2018134; eidem, US 4406906 (1979, 1983 to Bayer). Effect on associative learning in aging rabbits: R. A. Deyo et al., Science 243, 809 (1989). GC and LC determns in biological fluids: G. J. Krol et al., J. Chromatogr. 305, 105 (1984). Clinical trial in prophylaxis of cerebral vasospasm: G. S. Allen et al., N. Engl. J. Med. 308, 619 (1983). Toxicology: H. Schlüter, Arzneim.-Forsch. 36, 1733 (1986). Series of articles on clinical pharmacology and therapeutic use: Am. J. Cardiol. 55(3), 139B-153B (1985).
Properties: Crystals from petr ether/acetic ester, mp 125°. LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter).
Melting point: mp 125°
Toxicity data: LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter)
 
Derivative Type: (+)-Form
Properties: [a]D20 +7.9° (c = 0.439 in dioxane).
Optical Rotation: [a]D20 +7.9° (c = 0.439 in dioxane)
 
Derivative Type: (-)-Form
Properties: [a]D20 -7.93° (c = 0.374 in dioxane).
Optical Rotation: [a]D20 -7.93° (c = 0.374 in dioxane)
 
Therap-Cat: Vasodilator (cerebral).
Keywords: Calcium Channel Blocker; Dihydropyridine Derivatives; Vasodilator (Cerebral).