Home > Name List By 3 > 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 123524-52-7 , 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
    2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: CS-905; RS-9054; Azalnidipine; Calblock; NCGC00167436-01;3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
    2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;123524-52-7; Azelnidipine [INN]; CS 905; AG-D-50614;
  • CAS Registry Number:
  • Flash Point: 709.3ºCat 760 mmHg
  • Boiling Point: 709.3ºCat 760 mmHg
  • Density: 1.33 g/cm3
  • Refractive index: 1.658
  • Safety Statements: 26-39
  • Hazard Symbols: Xn
  • Flash Point: 709.3ºCat 760 mmHg
  • Molecular Weight: 582.64626
  • InchiKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N
  • InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-
    16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-
    8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
  • Risk Statements: 22-41
  • Molecular Formula: C33H34N4O6
  • Molecular Structure:CAS No:123524-52-7 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl<br />2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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References of 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Azelnidipine
CAS Registry Number: 123524-52-7
CAS Name: 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
Synonyms: (±)-3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Manufacturers' Codes: CS-905; RS-9054
Trademarks: Calblock (Sankyo)
Molecular Formula: C33H34N4O6
Molecular Weight: 582.65
Percent Composition: C 68.03%, H 5.88%, N 9.62%, O 16.48%
Literature References: Dihydropyridine L-type calcium channel blocker. Prepn: H. Koike et al., EP 266922; eidem, US 4772596 (both 1988 to Sankyo); T. Kobayashi et al., Chem. Pharm. Bull. 43, 797 (1995). Clinical evaluation in hypertension: M. Arita et al., J. Cardiovasc. Pharmacol. 33, 186 (1999). Review of pharmacology: Y. Yagil, A. Lustig, Cardiovasc. Drug Rev. 13, 137-148 (1995); of development, pharmacokinetics, safety, and clinical experience: H. Koike et al., Annu. Rep. Sankyo Res. Lab. 54, 1-64 (2002); of pharmacology and clinical experience: K. Wellington, L. J. Scott, Drugs 63, 2613-2621 (2003).
Properties: Pale yellow to yellow crystalline powder, mp 122-123°. Insol in water. pKa 7.89. LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally (Koike).
Melting point: mp 122-123°
pKa: pKa 7.89
Toxicity data: LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives.