Home > Name List By 1 > 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4- yl]benzimidazol-2-amine

CAS No 68844-77-9 , 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-
yl]benzimidazol-2-amine

  • Name: 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-
    yl]benzimidazol-2-amine
  • Synonyms: 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-
    yl]benzimidazol-2-amine; Laridal;Hismanal; Paralergin; Alermizol; Retolen; Histaminos; Astemison; Kelp; Histamen;
  • CAS Registry Number:
  • Density: 1.2 g/cm3
  • Refractive index: 1.623
  • Safety Statements: 26-36
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 272-441-9
  • Molecular Weight: 458.570343
  • InchiKey: GXDALQBWZGODGZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)
    30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,
    14-20H2,1H3,(H,30,31)
  • Risk Statements: R22;R36/37/38
  • Molecular Formula: C28H31FN4O
  • Molecular Structure:CAS No:68844-77-9 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-<br />yl]benzimidazol-2-amine

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References of 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]piperidin-4-
yl]benzimidazol-2-amine
Title: Astemizole
CAS Registry Number: 68844-77-9
CAS Name: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
Synonyms: 1-(p-fluorobenzyl)-2-[[1-(p-methoxyphenethyl)-4-piperidyl]amino]benzimidazole
Manufacturers' Codes: R-43512
Trademarks: Astemisan (Zdravlje); Hismanal (Janssen); Histamen (Polifarma); Histaminos (Lesvi); Kelp (Omni); Laridal (Elfar-Drag); Metodik (Labinca); Novo-Nastizol A (Bago); Paralergin (Vita); Retolen (Byk Elmu); Waruzol (Farmanic)
Molecular Formula: C28H31FN4O
Molecular Weight: 458.57
Percent Composition: C 73.34%, H 6.81%, F 4.14%, N 12.22%, O 3.49%
Literature References: Nonsedating-type histamine H1-receptor antagonist. Prepn: F. Janssens et al., EP 5318; eidem, US 4219559 (1979, 1980 both to Janssen). Pharmacology: J. Van Wauwe et al., Arch. Int. Pharmacodyn. Ther. 251, 39 (1981); A. Wauquier, C. J. E. Niemegeers, Eur. J. Pharmacol. 72, 245 (1981). In vitro and in vivo binding characteristics: P. M. Laduron et al., Mol. Pharmacol. 21, 294 (1982). Effect on human psychomotor performance: T. Seppala, K. Savolainen, Curr. Ther. Res. 31, 638 (1982). Clinical study in treatment of hay fever: J. Callier et al., ibid. 29, 24 (1981). Mutagenicity study: P. Vanparys et al., Arch. Toxicol. 50, 167 (1982). Review of pharmacology and clinical trials: D. M. Richards et al., Drugs 28, 38-61 (1984). Comprehensive description: A. M. Al-Obaid, M. S. Mian, Anal. Profiles Drug Subs. 20, 173-208 (1991).
Properties: Crystals from 2,2￠-oxybispropane, mp 172.9°. Freely sol in organic solvents. Practically insol in water. uv max (ethanol): 219, 249, 286 nm (e 27250.229, 6480.293, 8634.280); (0.1N HCl): 209, 277 nm (e 57889.908, 18073.394).
Melting point: mp 172.9°
Absorption maximum: uv max (ethanol): 219, 249, 286 nm (e 27250.229, 6480.293, 8634.280)
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic.