Home > Name List By 6 > 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H- benzimidazol-2-one

CAS No 57808-66-9 , 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-
benzimidazol-2-one

  • Name: 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-
    benzimidazol-2-one
  • Synonyms: Domperidona; Lopac-D-122; Domperidonum [INN-Latin]; Nauzelin;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-
    benzimidazol-2-one; NSC299589; Domperidonum;Motilium; 57808-66-9; Domperidon;
  • CAS Registry Number:
  • Melting Point: 242.5 ºC
  • Density: 1.341 g/cm3
  • Water Solubility: DMSO: >10 mg/mL
  • Safety Statements: R62;R63
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 260-968-7
  • Molecular Weight: 425.91126
  • InchiKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26
    (13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,
    8-13H2,(H,24,29)(H,25,30)
  • Risk Statements: S26;S36
  • Molecular Formula: C22H24ClN5O2
  • Molecular Structure:CAS No:57808-66-9 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-<br />benzimidazol-2-one

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References of 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-
benzimidazol-2-one
Title: Domperidone
CAS Registry Number: 57808-66-9
CAS Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Synonyms: 5-chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone
Manufacturers' Codes: R-33812
Trademarks: Euciton (Roux-Ocefa); Evoxin (Sterling Winthrop); Gastronorm (Janssen); Mod (Irbi); Motilium (Janssen); Nauzelin (Janssen); Peridon (Italchimici); Peridys (Robapharm)
Molecular Formula: C22H24ClN5O2
Molecular Weight: 425.91
Percent Composition: C 62.04%, H 5.68%, Cl 8.32%, N 16.44%, O 7.51%
Literature References: A novel in vitro dopamine antagonist with antinauseant properties. Prepn: J. Vandenberk et al., DE 2632870; eidem, US 4066772 (1977, 1978 both to Janssen). Pharmacology: C. Ennis et al., J. Pharm. Pharmacol. 31, Suppl., 14P (1979). Gastrokinetic properties: J. M. Van Neuten et al., Life Sci. 23, 453 (1978). 3H-domperidone studies: M. P. Martres et al., ibid. 1781; M. Baudry et al., Arch. Pharmacol. 308, 231 (1979). Clinical studies: A. J. Reyntjens et al., Arzneim.-Forsch. 28, 1194 (1978); D. B. Wilson, J. W. Dundee, Anaesthesia 34, 765 (1979). Review of pharmacology, pharmacokinetics and therapeutic efficacy: R. N. Brogden et al., Drugs 24, 360-400 (1982).
Properties: Crystals from DMF/water, mp 242.5°.
Melting point: mp 242.5°
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Dopamine Receptor Antagonist.