Home > Name List By 1 > 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl] imidazolidin-2-one

CAS No 106516-24-9 , 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]
imidazolidin-2-one

  • Name: 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]
    imidazolidin-2-one
  • Synonyms: Serdolect; Sertindolum [INN-Latin]; Sertindolum; Sertindol [INN-Spanish];SerLect;1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]
    imidazolidin-2-one; CHEBI:9122; Sertindol; sertindole hydrochloride;
  • CAS Registry Number:
  • Flash Point: 311.9°C
  • Boiling Point: 592.1°Cat760mmHg
  • Density: 1.36g/cm3
  • Refractive index: 1.67
  • Safety Statements: Hazard Codes XiRisk Statements 36/37/38Safety Statements 26RTECS NJ0621100
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 311.9°C
  • Molecular Weight: 440.940843
  • InchiKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-
    5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,
    27,31)
  • Risk Statements: 36/37/38
  • Molecular Formula: C24H26ClFN4O
  • Molecular Structure:CAS No:106516-24-9 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]<br />imidazolidin-2-one

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References of 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]
imidazolidin-2-one
Title: Sertindole
CAS Registry Number: 106516-24-9
CAS Name: 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Synonyms: 5-chloro-1-(4-fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-1H-indole
Manufacturers' Codes: Lu-23-174
Trademarks: Serdolect (Lundbeck)
Molecular Formula: C24H26ClFN4O
Molecular Weight: 440.94
Percent Composition: C 65.37%, H 5.94%, Cl 8.04%, F 4.31%, N 12.71%, O 3.63%
Literature References: Combined dopamine (D2) and serotonin (5-HT2) receptor antagonist. Prepn: J. K. Perregaard, EP 200322; idem, US 4710500 (1986, 1987 both to Lundbeck); idem et al., J. Med. Chem. 35, 1092 (1992). Neuropharmacology and receptor binding study: C. Sanchez et al., Drug Dev. Res. 22, 239 (1991). Reviews of clinical efficacy and safety: J. M. Kane, Int. Clin. Psychopharmacol. 13, Suppl. 3, S59-S64 (1997); A. S. Hale, ibid. S65-S70.
Properties: Crystals from acetone, mp 154-155°. Second crystal modification from 2-propanol + ethyl acetate, mp 166°.
Melting point: mp 154-155°; mp 166°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Serotonin-Dopamine Antagonist.