Home > Name List By 4 > 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1, 2]cyclohepta[2, 4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]pi...

CAS No 193275-84-2 , 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,
2]cyclohepta[2,
4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide

  • Name: 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,
    2]cyclohepta[2,
    4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
  • Synonyms: AC1L3WMQ; 1o5m; Sch66336; Lonafarnib [USAN];Sarasar; 193275-84-2; Sch 66336; Sch-66336; Lonafarnib (USAN/INN);4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,
    2]cyclohepta[2,
    4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide;
  • CAS Registry Number:
  • Flash Point: 383.5°C
  • Boiling Point: 710.4°Cat760mmHg
  • Density: 1.536
  • Flash Point: 383.5°C
  • Molecular Weight: 638.82164
  • InchiKey: DHMTURDWPRKSOA-RUZDIDTESA-N
  • InChI: InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25
    (26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/
    h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1
  • Molecular Formula: C27H31Br2ClN4O2
  • Molecular Structure:CAS No:193275-84-2 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,<br />2]cyclohepta[2,<br />4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide

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193275-84-2 Lonafarnib

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193275-84-2 1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-

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193275-84-2 1-Piperidinecarboxamide,4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-

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References of 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[1,
2]cyclohepta[2,
4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
Title: Lonafarnib
CAS Registry Number: 193275-84-2
CAS Name: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide
Manufacturers' Codes: Sch-66336
Trademarks: Sarasar (Schering-Plough)
Molecular Formula: C27H31Br2ClN4O2
Molecular Weight: 638.82
Percent Composition: C 50.76%, H 4.89%, Br 25.02%, Cl 5.55%, N 8.77%, O 5.01%
Literature References: Tricyclic farnesyl protein transferase inhibitor. Prepn: R. J. Doll et al., WO 9723478; eidem, US 5874442 (1997, 1999 both to Schering-Plough); F. G. Njoroge et al., J. Med. Chem. 41, 4890 (1998). Improved prepn: S.-C. Kuo et al., J. Org. Chem. 68, 4984 (2003). Crystal structure of complex with farnesyl protein transferase: C. L. Strickland et al., J. Med. Chem. 42, 2125 (1999). LC/MS/MS determn in plasma: N. M. G. Appels et al., Rapid Commun. Mass Spectrom. 19, 2187 (2005). Antitumor activity in human xenograft and transgenic mouse cancer models: M. Liu et al., Cancer Res. 58, 4947 (1998). Clinical evaluation in cancer: A. A. Adjei et al., ibid. 60, 1871 (2000). Inhibition of P-glycoprotein mediated drug efflux: E. Wang et al., ibid. 61, 7525 (2001). Clinical evaluation with paclitaxel in non-small cell lung cancer: E. S. Kim et al., Cancer 104, 561 (2005).
Properties: White solid. Crystals from acetone, mp 214.5-215.9° (monohydrate); anhydrous form mp 222-223°. [a]D25 = +49.1° (c = 0.21 in methanol).
Melting point: mp 214.5-215.9° (monohydrate); mp 222-223°
Optical Rotation: [a]D25 = +49.1° (c = 0.21 in methanol)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Farnesyl Transferase Inhibitors.