Home > Name List By 3 > 3-(cyclopropylmethoxy)-N-(3, 5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

CAS No 162401-32-3 , 3-(cyclopropylmethoxy)-N-(3,
5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

  • Name: 3-(cyclopropylmethoxy)-N-(3,
    5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
  • Synonyms: 1xoq;162401-32-3; 1xmu;3-(cyclopropylmethoxy)-N-(3,
    5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide; Daliresp; 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE; DAXAS;
  • CAS Registry Number:
  • Density: 1.466 g/cm3
  • Refractive index: 1.603
  • Molecular Weight: 403.207466
  • InchiKey: MNDBXUUTURYVHR-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13
    (26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
  • Molecular Formula: C17H14Cl2F2N2O3
  • Molecular Structure:CAS No:162401-32-3 3-(cyclopropylmethoxy)-N-(3,<br />5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

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References of 3-(cyclopropylmethoxy)-N-(3,
5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Title: Roflumilast
CAS Registry Number: 162401-32-3
CAS Name: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
Manufacturers' Codes: BY-217
Trademarks: Daxas (Altana)
Molecular Formula: C17H14Cl2F2N2O3
Molecular Weight: 403.21
Percent Composition: C 50.64%, H 3.50%, Cl 17.59%, F 9.42%, N 6.95%, O 11.90%
Literature References: Selective phosphodiesterase 4 (PDE4) inhibitor. Prepn: D. Flockerzi et al., WO 9501338; H. Amschler, US 5712298 (1995, 1998 both to Byk-Gulden). Pharmacology: A. Hatzelmann, C. Schudt, J. Pharmacol. Exp. Ther. 297, 267 (2001); D. S. Bundschuh et al., ibid. 280. Clinical evaluation in allergic rhinitis: B. M. W. Schmidt et al., J. Allergy Clin. Immunol. 108, 530 (2001); in exercise-induced asthma: W. Timmer et al., J. Clin. Pharmacol. 42, 297 (2002); in COPD: K. F. Rabe et al., Lancet 366, 563 (2005). Comparative review with cilomilast: M. A. Giembycz, Monaldi Arch. Chest Dis. 57, 48-64 (2002).
Properties: Crystals from isopropanol, mp 158°.
Melting point: mp 158°
Therap-Cat: Antiasthmatic; in treatment of chronic obstructive pulmonary disease.
Keywords: Antiasthmatic (Nonbronchodilator); Phosphodiesterase Inhibitor.