Home > Name List By 4 > 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid

CAS No 153559-49-0 , 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
acid

  • Name: 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
    acid
  • Synonyms: 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
    acid;Targretin; Targret; Targrexin; LGD1069; Targretin-gel; Targretyn; 153559-49-0; bexaroteno; LGD 1069;
  • CAS Registry Number:
  • Density: 1.042
  • Molecular Weight: 348.47792
  • InchiKey: NAVMQTYZDKMPEU-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,
    3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,
    3-6H3,(H,25,26)
  • Molecular Formula: C24H28O2
  • Molecular Structure:CAS No:153559-49-0 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic<br />acid
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153559-49-0 Bexarotene

  • India Manus Aktteva null
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, null,nullIndia
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153559-49-0 Bexarotene

  • China Betapharma(Shanghai)Co., Ltd. null
  • Tel: +86-(21)-33538380
  • Fax: +86-(21)-32082820
  • Address: No.17#-6D. 830 Lane, Maotai Road, Shanghai 200336, null,nullChina
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153559-49-0 Bexarotene

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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153559-49-0 Bexarotene

  • China TaiZhou HiKong Chemical Co., Ltd. null
  • Tel: +86-18967213045,13957694715
  • Fax: +86-(580)-6033180,6034626
  • Address: Taizhou Economic Technical Development Zone, Taizhou, Zhejiang 318000, null,nullChina
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153559-49-0 Bexarotene

  • Bexarotene 153559-49-0 Bicalutamide 90357-06-5 Biapenem 120410-24-4 Bimatoprost 155206-00-1 Blonanserin(AD-5423,Lonasen) 132810-10-7 Brivanib Alaninate 649735-63-7 Brinzolamide 138890-62-7 Bortezomib 179324-69-7 Bosutinib 380843-75-4
  • China Wuhan Sunrise Technology development company limited [Manufacturers]
  • Tel: +86-27-83314682
  • Fax: 86 27 83314682
  • Address: Floor 5, Wunan Road No.15, Haixia Investment Zone, Wujiashan Wuhan, China Wuhan,HubeiChina
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153559-49-0 Bexarotene

  • China GrowingChem (Shanghai) Co., Ltd [Manufacturer]
  • Tel: 86-21-51320180/ 86-21-51320373
  • Fax: 86-21-51320178
  • Address: 601B, No.1043, Halei Rd,
    Zhangjiang Hi-Tech Park,
    Shanghai, Postcode 201203, China null,nullChina
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153559-49-0 Bexarotene

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153559-49-0 BEXAROTENE

  • China Apichem Chemical Technology Co., Ltd [Manufacturer]
  • Tel: 86-137-6120-5405/ 86-21-3762-3285
  • Address: Apichem Chemical Technology Co., Ltd
    room 102, No.22,lane 288,
    Qianshao Road,
    Pudong, shanghai 201201 China null,nullChina
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153559-49-0 Bexarotene

  • Bexarotene, 98,0%
  • United States LC Laboratories [Manufacturer]
  • Tel: 781-937-0777
  • Fax: 781-938-5420
  • Address: LC Laboratories
    165 New Boston Street
    Woburn, MA 01801 USA null,nullUnited States
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153559-49-0 BEXAROTENE

  • China Shanghai Yingxuan Chempharm Co., Ltd. [Manufacturer]
  • Tel: 86-21-50323911
  • Fax: 86-21-50323911
  • Address: Shanghai Yingxuan Chempharm Co., Ltd.
    No.1-303, 666 Taierzhuang Rd.,
    Pudong, Shanghai,
    CN-201206,China null,nullChina
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References of 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
acid
Title: Bexarotene
CAS Registry Number: 153559-49-0
CAS Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Manufacturers' Codes: SR-11247; LGD-1069
Trademarks: Targretin (Ligand)
Molecular Formula: C24H28O2
Molecular Weight: 348.48
Percent Composition: C 82.72%, H 8.10%, O 9.18%
Literature References: Selective retinoid X receptor (RXR) agonist. Prepn: M. F. Boehm et al., WO 9321146 (1993 to Ligand Pharm.); M. L. Dawson et al., US 5466861 (1995 to SRI Int.; La Jolla Cancer Res. Found.); and structure-activity study: M. F. Boehm et al., J. Med. Chem. 37, 2930 (1994); M. I. Dawson et al., ibid. 38, 3368 (1995). Chemopreventive effect in rat mammary carcinoma: M. M. Gottardis et al., Cancer Res. 56, 5566 (1996). Effect on glucose homeostasis in exptl diabetes: R. Mukherjee et al., Nature 386, 407 (1997). Clinical pharmacokinetics and evaluation in advanced cancers: V. A. Miller et al., J. Clin. Oncol. 15, 790 (1997). Clinical evaluation in cutaneous T-cell lymphoma: D. Breneman et al., Arch. Dermatol. 138, 325 (2002).
Properties: White solid from methylene chloride, mp 230-231° (Dawson, 1995); also reported as white crystals, mp 234° (Boehm, 1994). uv max (methanol): 264 nm (e 16400).
Melting point: mp 230-231° (Dawson, 1995); mp 234° (Boehm, 1994)
Absorption maximum: uv max (methanol): 264 nm (e 16400)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Retinoids and Analogs.