Home > Name List By 4 > 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid India

CAS No 153559-49-0 , 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
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  • Name: 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
    acid
  • Synonyms: 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
    acid;Targretin; Targret; Targrexin; LGD1069; Targretin-gel; Targretyn; 153559-49-0; bexaroteno; LGD 1069;
  • CAS Registry Number:
  • Density: 1.042
  • Molecular Weight: 348.47792
  • InchiKey: NAVMQTYZDKMPEU-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,
    3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,
    3-6H3,(H,25,26)
  • Molecular Formula: C24H28O2
  • Molecular Structure:CAS No:153559-49-0 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic<br />acid

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References of 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic
acid
Title: Bexarotene
CAS Registry Number: 153559-49-0
CAS Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Manufacturers' Codes: SR-11247; LGD-1069
Trademarks: Targretin (Ligand)
Molecular Formula: C24H28O2
Molecular Weight: 348.48
Percent Composition: C 82.72%, H 8.10%, O 9.18%
Literature References: Selective retinoid X receptor (RXR) agonist. Prepn: M. F. Boehm et al., WO 9321146 (1993 to Ligand Pharm.); M. L. Dawson et al., US 5466861 (1995 to SRI Int.; La Jolla Cancer Res. Found.); and structure-activity study: M. F. Boehm et al., J. Med. Chem. 37, 2930 (1994); M. I. Dawson et al., ibid. 38, 3368 (1995). Chemopreventive effect in rat mammary carcinoma: M. M. Gottardis et al., Cancer Res. 56, 5566 (1996). Effect on glucose homeostasis in exptl diabetes: R. Mukherjee et al., Nature 386, 407 (1997). Clinical pharmacokinetics and evaluation in advanced cancers: V. A. Miller et al., J. Clin. Oncol. 15, 790 (1997). Clinical evaluation in cutaneous T-cell lymphoma: D. Breneman et al., Arch. Dermatol. 138, 325 (2002).
Properties: White solid from methylene chloride, mp 230-231° (Dawson, 1995); also reported as white crystals, mp 234° (Boehm, 1994). uv max (methanol): 264 nm (e 16400).
Melting point: mp 230-231° (Dawson, 1995); mp 234° (Boehm, 1994)
Absorption maximum: uv max (methanol): 264 nm (e 16400)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Retinoids and Analogs.