CAS No 151096-09-2 , 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,
4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-
carboxylic acid

Title: Moxifloxacin
CAS Registry Number: 151096-09-2
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C21H24FN3O4
Molecular Weight: 401.43
Percent Composition: C 62.83%, H 6.03%, F 4.73%, N 10.47%, O 15.94%
Literature References: Fluorinated quinolone antibacterial. Prepn: U. Petersen et al., EP 550903 (1993 to Bayer). Antibacterial spectrum in vitro: J. M. Woodcock et al., Antimicrob. Agents Chemother. 41, 101 (1997). Activity vs Mycobacterium tuberculosis: B. Ji et al., ibid. 42, 2066 (1998). HPLC determn in serum: C. M. Tobin et al., J. Antimicrob. Chemother. 42, 278 (1998). Clinical pharmacokinetics: H. Stass et al., Antimicrob. Agents Chemother. 42, 2060 (1998). Review of pharmacology and clinical experience: M. Miravitlles, Expert Opin. Pharmacother. 6, 283-293 (2005).
Properties: mp 203-208° (dec). [a]23D -193°.
Melting point: mp 203-208°
Optical Rotation: [a]23D -193°
 
Derivative Type: Hydrochloride
CAS Registry Number: 186826-86-8
Manufacturers' Codes: Bay-12-8039
Trademarks: Actimax (Sankyo); Actira (Bayer); Avalox (Bayer); Avelox (Bayer); Octegra (Bayer); Proflox (Esteve); Vigamox (Alcon)
Molecular Formula: C21H24FN3O4.HCl
Molecular Weight: 437.89
Percent Composition: C 57.60%, H 5.75%, F 4.34%, N 9.60%, O 14.61%, Cl 8.10%
Properties: Slightly yellow to yellow crystalline powder, mp 324-325° (dec). [a]25D -256° (c = 0.5 in water).
Melting point: Slightly yellow to yellow crystalline powder, mp 324-325°
Optical Rotation: [a]25D -256° (c = 0.5 in water)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.