Home > Name List By 1 > 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4- oxoquinoline-3-carboxylic acid

CAS No 119914-60-2 , 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-
oxoquinoline-3-carboxylic acid

  • Name: 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-
    oxoquinoline-3-carboxylic acid
  • Synonyms: Raxar; CHEMBL583; CCRIS 7284; Grepafloxacin (unspecified); 119914-60-2; UNII-L1M1U2HC31;1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-
    oxoquinoline-3-carboxylic acid; CHEBI:117136; AC1L2I4Z; Grepafloxacin [INN];
  • CAS Registry Number:
  • Melting Point: 189-192 ºC
  • Flash Point: 322.7°C
  • Boiling Point: 610°Cat760mmHg
  • Density: 1.366
  • Flash Point: 322.7°C
  • Molecular Weight: 359.394683
  • InchiKey: AIJTTZAVMXIJGM-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18
    (24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)
  • Molecular Formula: C19H22FN3O3
  • Molecular Structure:CAS No:119914-60-2 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-<br />oxoquinoline-3-carboxylic acid

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References of 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-
oxoquinoline-3-carboxylic acid
Title: Grepafloxacin
CAS Registry Number: 119914-60-2
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C19H22FN3O3
Molecular Weight: 359.39
Percent Composition: C 63.50%, H 6.17%, F 5.29%, N 11.69%, O 13.36%
Literature References: Fluorinated quinolone antibacterial. Prepn: J. M. Domagala et al., WO 8906649; eidem, US 4920120 (1989, 1990 both to Warner-Lambert); S. E. Hagen et al., J. Med. Chem. 34, 1155 (1991). Comparative in vitro activity: F. Marco et al., J. Antimicrob. Chemother. 33, 647 (1994); R. C. Arduino et al., ibid. 34, 403. HPLC determn in human bronchoalveolar lavage samples: J. M. Woodcock et al., FEMS Microbiol. Lett. 119, 315 (1994). Clinical pharmacokinetics: J. Child et al., Antimicrob. Agents Chemother. 39, 513 (1995). Tissue concentration in lung: P. J. Cook et al., J. Antimicrob. Chemother. 35, 317 (1995). Review of pharmacology and clinical trials: A. J. Wagstaff, J. A. Balfour, Drugs 53, 817-824 (1997).
 
Derivative Type: Dihydrate
Properties: mp 190-192°.
Melting point: mp 190-192°
 
Derivative Type: Hydrochloride
CAS Registry Number: 161967-81-3
Manufacturers' Codes: OPC-17116
Trademarks: Raxar (Glaxo Wellcome)
Molecular Formula: C19H22FN3O3.HCl
Molecular Weight: 395.86
Percent Composition: C 57.65%, H 5.86%, F 4.80%, N 10.61%, O 12.13%, Cl 8.96%
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.