Title: Gatifloxacin
CAS Registry Number: 112811-59-3
CAS Name: 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Trademarks: Tequin (BMS); Zymar (Allergan)
Molecular Formula: C19H22FN3O4
Molecular Weight: 375.39
Percent Composition: C 60.79%, H 5.91%, F 5.06%, N 11.19%, O 17.05%
Literature References: Fluorinated quinolone antibacterial. Prepn: K. Masuzawa
et al., EP 230295;
eidem, US 4980470 (1987, 1990 both to Kyorin); J. P. Sanchez
et al., J. Med. Chem. 38, 4478 (1995); of the sesquihydrate: T. Matsumoto
et al., US 5880283 (1999 to Kyorin).
In vitro antibacterial activity: A. Bauernfeind,
J. Antimicrob. Chemother. 40, 639 (1997); H. Fukuda
et al., Antimicrob. Agents Chemother. 42, 1917 (1998). Clinical pharmacokinetics: M. Nakashima
et al., ibid. 39, 2635 (1995). Clinical study in urinary tract infection: H. Nito,
10th Mediterranean Congr. Chemother. 1996, 327; in respiratory tract infection: S. Sethi,
Expert Opin. Pharmacother. 4, 1847 (2003).
Properties: Pale yellow prisms from methanol as hemihydrate, mp 162°.
Melting point: mp 162°
Derivative Type: Sesquihydrate
CAS Registry Number: 180200-66-2
Manufacturers' Codes: AM-1155
Molecular Formula: C19H22FN3O4.1?H2O
Molecular Weight: 384.40
Percent Composition: C 59.37%, H 6.03%, F 4.94%, N 10.93%, O 18.73%
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.
