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CAS No 144-83-2 , 4-amino-N-pyridin-2-ylbenzenesulfonamide

  • Name: 4-amino-N-pyridin-2-ylbenzenesulfonamide
  • Synonyms: Relbapiridina; 2-Sulfanilamidopyridine; Sulfidin; Sulfidine; Coccoclase; Streptosilpyridine; 2-Sulfapyridine;4-amino-N-pyridin-2-ylbenzenesulfonamide;Sulphapyridine;
  • CAS Registry Number:
  • Melting Point: 191-193 ºC
  • Flash Point: 240.2°C
  • Boiling Point: 473.5°Cat760mmHg
  • Density: 1.432g/cm3
  • Refractive index: 1.674
  • Water Solubility: <0.1 G/100 ML AT 22 ºC
  • Safety Statements: Moderately toxic by intraperitoneal and intravenous routes. Slightly toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • Hazard Symbols: Xi
  • Flash Point: 240.2°C
  • EINECS: 205-642-7
  • Molecular Weight: 249.28894
  • InchiKey: GECHUMIMRBOMGK-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,
    16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
  • Risk Statements: 36/37/38
  • Molecular Formula: C11H11N3O2S
  • Molecular Structure:CAS No:144-83-2 4-amino-N-pyridin-2-ylbenzenesulfonamide

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References of 4-amino-N-pyridin-2-ylbenzenesulfonamide
Title: Sulfapyridine
CAS Registry Number: 144-83-2
CAS Name: 4-Amino-N-2-pyridinylbenzenesulfonamide
Synonyms: dagenan; N1-2-pyridylsulfanilamide; 2-sulfanilamidopyridine; 2-(p-aminobenzenesulfonamido)pyridine
Manufacturers' Codes: M & B 693
Molecular Formula: C11H11N3O2S
Molecular Weight: 249.29
Percent Composition: C 53.00%, H 4.45%, N 16.86%, O 12.84%, S 12.86%
Literature References: Prepn: A. J. Ewins, M. A. Phillips, GB 512145 (1939); eidem, US 2275354 (1942); R. Winterbottom, J. Am. Chem. Soc. 62, 160 (1940). Metabolism: R. Wien, J. Hampton, J. Pharmacol. Exp. Ther. 84, 211 (1945). Toxicology: R. Wien et al., ibid. 203. GC-MS determn in edible animal tissues: A. E. Mooser, H. Koch, J. AOAC Int. 76, 976 (1993). Efficacy and proposed mechanism of action in dermatological disease: O. J. Stone, Med. Hypotheses 31, 99 (1990). Clinical evaluation in ocular cicatricial pemphigoid: M. J. Elder et al., Br. J. Ophthalmol. 80, 549 (1996).
Properties: Crystals from alc, mp 190-191°. One gram dissolves in ~3500 ml water, 440 ml alcohol, 65 ml acetone. Freely sol in dil mineral acids and in aq solns of KOH and NaOH. More sol in warm sugar solns than in water alone. The aq soln is neutral. LD50 orally in mice: 7.5 mg/g (Wien).
Melting point: mp 190-191°
Toxicity data: LD50 orally in mice: 7.5 mg/g (Wien)
 
Derivative Type: Sodium salt monohydrate
CAS Registry Number: 127-57-1
Synonyms: Soluble sulfapyridine
Molecular Formula: C11H10N3NaO2S.H2O
Molecular Weight: 289.29
Percent Composition: C 45.67%, H 4.18%, N 14.53%, Na 7.95%, O 16.59%, S 11.08%
Properties: On prolonged exposure to humid air it absorbs CO2, liberates sulfapyridine, becomes incompletely sol in water. One gram dissolves in ~1.5 ml water, 10 ml alcohol. pH of 5% aq soln: 11.4. LD50 orally in mice: 2.7 mg/g (Wien).
Toxicity data: LD50 orally in mice: 2.7 mg/g (Wien)
 
Therap-Cat: In treatment of dermatitis herpetiformis; antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides; Dermatitis Herpetiformis Suppressant.