Home > Name List By other > (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11, 17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15, 16-decahydro... China

CAS No 127-31-1 , (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,
16-decahydrocyclopenta[a]phenanthren-3-one Search by region : China

  • Name: (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,
    16-decahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: Fludrone;Fluohydrisone; Fluorocortisone; Fludrocortone;(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,
    17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,
    16-decahydrocyclopenta[a]phenanthren-3-one; Fluorocortisol; Florinef; Fludronef; Alflorone; Astonin-H;
  • CAS Registry Number:
  • Flash Point: 301.6°C
  • Boiling Point: 575.1°C at 760 mmHg
  • Density: 1.3g/cm3
  • Refractive index: 1.563
  • Safety Statements: Poison by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−. See also PREDNISONE.
  • Flash Point: 301.6°C
  • EINECS: 204-833-2
  • Molecular Weight: 380.450363
  • InchiKey: AAXVEMMRQDVLJB-BULBTXNYSA-N
  • InChI: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,
    17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,
    1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
  • Molecular Formula: C21H29FO5
  • Molecular Structure:CAS No:127-31-1 (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,<br />17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,<br />16-decahydrocyclopenta[a]phenanthren-3-one

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References of (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,
17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,
16-decahydrocyclopenta[a]phenanthren-3-one
Title: Fludrocortisone
CAS Registry Number: 127-31-1
CAS Name: (11b)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione
Synonyms: 9a-fluorohydrocortisone; 9a-fluoro-17-hydroxycorticosterone; 9a-fluorocortisol; fluodrocortisone; fluohydrisone; fluohydrocortisone
Trademarks: Astonin H (Merck KGaA)
Molecular Formula: C21H29FO5
Molecular Weight: 380.45
Percent Composition: C 66.30%, H 7.68%, F 4.99%, O 21.03%
Literature References: Prepn: J. Fried, E. F. Sabo, J. Am. Chem. Soc. 76, 1455 (1954); GB 792224; J. Fried, US 2852511 (both 1958 to Olin Mathieson). Series of articles on pharmacology and metabolism: Arzneim.-Forsch. 21, 1103-1158 (1971). Comprehensive description of the acetate: K. Florey, Anal. Profiles Drug Subs. 3 281-306 (1974).
Properties: Crystals, dec 260-262°. [a]D23 +139° (c = 0.55 in 95% ethanol). uv max (ethanol): 239 nm (e 17600). Soly in water: 0.14 mg/ml.
Optical Rotation: [a]D23 +139° (c = 0.55 in 95% ethanol)
Absorption maximum: uv max (ethanol): 239 nm (e 17600)
 
Derivative Type: 21-Acetate
CAS Registry Number: 514-36-3
Trademarks: Florinef (BMS)
Molecular Formula: C23H31FO6
Molecular Weight: 422.49
Percent Composition: C 65.39%, H 7.40%, F 4.50%, O 22.72%
Properties: Crystals, polymorphic, mp 233-234° (occasionally mp 205-208°, resolidifying on further heating, then mp 226-228°). Crystallizing procedure: R. P. Graber, C. S. Snoddy, US 2957013 (1960 to Merck & Co.). [a]D23 +123° (c = 0.64 in chloroform). uv max (ethanol): 238 nm (e 16800). Soly (mg/ml): water 0.04; acetone 56; alc 20; chloroform 20; ether 4.
Melting point: Crystals, polymorphic, mp 233-234° (occasionally mp 205-208°, resolidifying on further heating, then mp 226-228°)
Optical Rotation: [a]D23 +123° (c = 0.64 in chloroform)
Absorption maximum: uv max (ethanol): 238 nm (e 16800)
 
Therap-Cat: Mineralocorticoid.
Therap-Cat-Vet: Mineralocorticoid.
Keywords: Mineralocorticoid.