Home > Name List By s > Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-...

CAS No 114899-77-3 , Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,(1'R,6R,6aR,7R,13S,14S,16R)-

  • Name: Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,(1'R,6R,6aR,7R,13S,14S,16R)-
  • Synonyms: Ecteinascidine 743; Et 743;Trabectedin; NSC 648766;Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,[6R-(6a,6ab,7b,13b,14b,16a,20R*)]-; Yondelis; Ecteinascidin 743;Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,(1'R,6R,6aR,7R,13S,14S,16R)-;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.53g/cm3
  • Refractive index: 1.723
  • Safety Statements: A poison by intravenous route. When heated to decomposition it emits toxic vapors of SOx and NOx.
  • Flash Point: °C
  • Molecular Weight: 761.91
  • InChI: InChI=1/C40H45N3O11S/c1-17-11-21-12-23-38(47)43-24-15-51-39(48)40(22-14-26(49-5)25(45)13-20(22)7-9-41-40)8-10-55-37(31(43)30(42(23)4)27(21)32(46)33(17)50-6)29-28(24)36-35(52-16-53-36)18(2)34(29)54-19(3)44/h11,13-14,23-24,30-31,37-38,41,45-47H,7-10,12,15-16H2,1-6H3/t23-,24-,30+,31+,37+,38-,40+/m0/s1
  • Molecular Formula: C39H43 N3 O11 S
  • Molecular Structure:CAS No:114899-77-3 Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,(1'R,6R,6aR,7R,13S,14S,16R)-

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114899-77-3 TRABECTEDINUM

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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114899-77-3 TRABECTEDIN

  • China Apichem Chemical Technology Co., Ltd [Manufacturer]
  • Tel: 86-137-6120-5405/ 86-21-3762-3285
  • Address: Apichem Chemical Technology Co., Ltd
    room 102, No.22,lane 288,
    Qianshao Road,
    Pudong, shanghai 201201 China null,nullChina
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114899-77-3 Ecteinascidin 743

  • Ecteinascidin 743, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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References of Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one,5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,(1'R,6R,6aR,7R,13S,14S,16R)-
Title: Ecteinascidins
Literature References: Family of tetrahydroisoquinoline alkaloids with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. Ecteinascidin 743 is the most abundant; bends DNA toward the major groove by selectively alkylating guanine from the minor groove. Prepn: K. L. Rinehart, T. G. Holt, WO 8707610; eidem, US 5089273 (1987, 1992 both to Univ. Illinois); and structures: K. L. Rinehart et al., J. Org. Chem. 55, 4512 (1990); R. Sakai et al., Proc. Natl. Acad. Sci. USA 89, 11456 (1992). Crystal structures: Y. Guan et al., J. Biomol. Struct. Dyn. 10, 793 (1993). Biosynthetic studies: R. G. Kerr, N. F. Miranda, J. Nat. Prod. 58, 1618 (1995).
 
Derivative Type: Trabectedin
CAS Registry Number: 114899-77-3
CAS Name: (1¢R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3¢,4¢,6,6a,7,13,14,16-octahydro-6¢,8,14-trihydroxy-7¢,9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1¢(2¢H)-isoquinolin]-19-one
Synonyms: ecteinascidin 743
Manufacturers' Codes: ET-743
Trademarks: Yondelis (PharmaMar)
Molecular Formula: C39H43N3O11S
Molecular Weight: 761.84
Percent Composition: C 61.48%, H 5.69%, N 5.52%, O 23.10%, S 4.21%
Literature References: Enantioselective total synthesis: E. J. Corey et al., J. Am. Chem. Soc. 118, 9202 (1996). In vitro antitumor activity: E. Isbicka et al., Ann. Oncol. 9, 981 (1998). HPLC determn in plasma: H. Rosing et al., J. Chromatogr. B 710, 183 (1998). Clinical pharmacokinetics: C. van Kesteren et al., Clin. Cancer Res. 6, 4725 (2000). Review of mechanism of action: G. J. Aune et al., Anti-Cancer Drugs 13, 545-555 (2002); of clinical development: C. van Kesteren et al., ibid. 14, 487-502 (2003); of metabolism and hepatotoxicity: J. H. Beumer et al., Pharmacol. Res. 51, 391-398 (2005).
Properties: [a]D25 +114° (c = 0.1 in methanol).
Optical Rotation: [a]D25 +114° (c = 0.1 in methanol)
 
Therap-Cat: Antineoplastic.