Home > Name List By other > (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2, 6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13, 16-trimethyl-6,7,8,12,1...

CAS No 110101-66-1 , (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,
6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,
16-trimethyl-6,7,8,12,14,15,16,
17-octahydrocyclopenta[a]phenanthren-3-one

  • Name: (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,
    6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,
    16-trimethyl-6,7,8,12,14,15,16,
    17-octahydrocyclopenta[a]phenanthren-3-one
  • Synonyms: (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,
    6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,
    16-trimethyl-6,7,8,12,14,15,16,
    17-octahydrocyclopenta[a]phenanthren-3-one; U 74006;Tirilazadum [INN-Latin]; PNU 74006F; 110101-66-1;
  • CAS Registry Number:
  • Flash Point: 445.4°C
  • Boiling Point: 812.9°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.646
  • Flash Point: 445.4°C
  • Molecular Weight: 624.85848
  • InchiKey: RBKASMJPSJDQKY-RBFSKHHSSA-N
  • InChI: InChI=1S/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,
    2)30(29)11-13-38(31,
    3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-
    34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,
    29-,31+,35-,37+,38+/m1/s1
  • Molecular Formula: C38H52N6O2
  • Molecular Structure:CAS No:110101-66-1 (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,<br />6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,<br />16-trimethyl-6,7,8,12,14,15,16,<br />17-octahydrocyclopenta[a]phenanthren-3-one

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110101-66-1 TIRILAZAD

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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110101-66-1 TIRILAZAD

  • United States 2A PharmaChem USA [Manufacturer]
  • Tel: 630-322-8887
  • Fax: 630-322-8885
  • Address: 2A PharmaChem USA
    5403 Patton Drive, Suite 208
    Lisle, Illinois 60532 null,nullUnited States
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References of (8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,
6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,
16-trimethyl-6,7,8,12,14,15,16,
17-octahydrocyclopenta[a]phenanthren-3-one
Title: Tirilazad
CAS Registry Number: 110101-66-1
CAS Name: (16a)-21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16-methylpregna-1,4,-9(11)-triene-3,20-dione
Molecular Formula: C38H52N6O2
Molecular Weight: 624.86
Percent Composition: C 73.04%, H 8.39%, N 13.45%, O 5.12%
Literature References: Member of a novel class of nonglucocorticoid, 21-aminosteroid antioxidants known as lazaroids which inhibit lipid peroxidation and have cytoprotectant activity. Prepn: J. M. McCall et al., WO 8701706; eidem, US 5175281 (1987, 1992 both to Upjohn). Inhibition of iron-dependent lipid peroxidation in vitro: J. M. Braughler et al., J. Biol. Chem. 262, 10438 (1987). HPLC determn in plasma: J. W. Cox, R. H. Pullen, J. Chromatogr. 424, 293 (1988). Clinical pharmacokinetics: J. C. Fleishaker et al., J. Clin. Pharmacol. 33, 175, 182 (1993). Veterinary evaluation in endotoxemia of neonatal calves: M. L. Rose, S. D. Semrad, Am. J. Vet. Res. 53, 2305 (1992). Review: E. D. Hall, Ann. Neurol. 32, S137-S142 (1992). Review of efficacy and mechanism of action in experimental models of subarachnoid hemorrhage: idem, Eur. J. Anaesthesiol. 13, 279-289 (1996); of clinical trials in acute ischemic stroke: Tirilazad International Steering Committee, Stroke 32, 2257-2265 (2000).
 
Derivative Type: Methanesulfonate monohydrate
CAS Registry Number: 111793-42-1
Synonyms: Tirilazad mesylate
Manufacturers' Codes: U-74006F
Trademarks: Freedox (Pharmacia & Upjohn)
Molecular Formula: C38H52N6O2.CH3SO3H.H2O
Molecular Weight: 738.98
Percent Composition: C 63.39%, H 7.91%, N 11.37%, O 12.99%, S 4.34%
Properties: mp 181-185° (dec). uv max: 234, 285 nm (e 52000, 17000). Log P (octanol/water): 8.
Melting point: mp 181-185° (dec)
Log P: Log P (octanol/water): 8
Absorption maximum: uv max: 234, 285 nm (e 52000, 17000)