CAS No 83919-23-7 , [(8S,9R,10S,11S,13S,14S,16R,
17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,
7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]
furan-2-carboxylate

Title: Mometasone Furoate
CAS Registry Number: 83919-23-7
CAS Name: (11b,16a)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
Synonyms: 9,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-(2-furoate)
Manufacturers' Codes: Sch-32088
Trademarks: Asmanex (Schering-Plough); Elocon (Schering-Plough); Nasonex (Schering-Plough)
Molecular Formula: C27H30Cl2O6
Molecular Weight: 521.43
Percent Composition: C 62.19%, H 5.80%, Cl 13.60%, O 18.41%
Literature References: Topical corticosteroid. Prepn: E. L. Shapiro, EP 57401; idem, US 4472393 (1982, 1984 both to Schering Corp.); E. L. Shapiro et al., J. Med. Chem. 30, 1581 (1987). LC-MS-MS determn in plasma: S. Sahasranaman et al., J. Chromatogr. B 819, 175 (2005). Clinical trial in psoriasis: R. S. Medansky et al., Semin. Dermatol. 6, 94 (1987); in seasonal allergic rhinitis: D. Graft et al., J. Allergy Clin. Immunol. 98, 724 (1996).
Properties: Crystals from aq methanol, mp 218-220°. [a]D26 +58.3° (dioxane). uv max (methanol): 247 nm (e 26300). Practically insol in water. Slightly sol in octanol; moderately sol in ethyl alcohol.
Melting point: mp 218-220°
Optical Rotation: [a]D26 +58.3° (dioxane)
Absorption maximum: uv max (methanol): 247 nm (e 26300)
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.