Trilostane
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Molecular Structure
Detailed Description
Trilostane
Synonyms: (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car;17-beta)-ph;4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril;4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile;4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
CAS: 13647-35-3
MF: C20H27NO3
MW: 329.43
EINECS: 237-133-0
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Inhibitor
Chemical Properties: Tan Crystals
Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer . antifungal, inhibits mitosis in metaphase .
Packing:1kg/foil bag or as required
Test Items Specification Test Results
Appearance white oralmost white,crystalline powder Conform
Solubility Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform
Identification A The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64. Conform
B Infraed absorption spectrophotometry. Conform
C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. Conform
D An orange-red color develop in methylene chloride layer. Conform
E It geves reaction (a) of sulphates. Conform
Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform
Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°
Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. Conform
Related substances Impurity J ≤0.20% Conform
Any other impurity ≤0.30% Conform
Total impurity ≤1.0% Conform
Boron ≤50ppm Conform
Sulphated ash ≤0.10% 0.06%
Loss on drying ≤0.5% 0.30%
Assay(on dried basis) 98.0~101.0% 99.5%
Conclusion The test results above BP2009
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- Trilostane
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