Dextromethorphan hydrobromide
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Molecular Structure
Detailed Description
Dextromethorphan hydrobromide
CAS: 6700-34-1
MF: C18H28BrNO2
MW: 370.32
mp 116-119°C
Fp 11 °C
storage temp. Store at RT
Chemical Properties White Solid
Usage An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).
Description :
Dextromethorphan Hydrobromide is the hydrobromide salt form of dextromethorphan, a synthetic,
addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors
on the cough center in the central nervous system, thereby suppressing the cough reflex.
Application :
DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.
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