Diethyl fluoromalonate,CAS 685-88-1

• Product NameDiethyl fluoromalonate,CAS 685-88-1
  CAS No.685-88-1
  Purity98%(Min,GC)
  Min Quantity300Metric Tons
  Price25~30
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  Molecular Structure

Detailed Description

What is diethyl fluoromalonate?
Diethyl fluoromalonate, CAS number 685-88-1, is an organic intermediate widely used in the fields of pharmaceuticals, agricultural chemicals, materials, dyestuff, industrial additives, etc. It is also known as diethyl 2-fluoromalonate, 1,3-diethyl 2-fluoropropanedioate, 2-fluoro-malonic acid diethyl ester, fluoromalonic acid diethyl ester, Ethyl fluoromalonate, etc.

Key applications of diethyl fluoromalonate
The already known key applications of Diethyl fluoromalonate include: used as pharmaceutical intermediate, in synthesizing fungicides, special materials, dyestuff, enzyme?inhibitors, fluoride-containing amino acids, fluoride-containing Chalcone, sedative, etc. The research and industrialization of diethyl fluoromalonate is still?at?the?beginning?stage, and more applications will be explored in the future.

Diethyl fluoromalonate as pharmaceutical intermediate
Diethyl fluoromalonate has been shown to be a valuable intermediate in the synthesis of alpha-fluoroalkanoic acids, including y-fluoroglutamic acid. It is also an intermediate for 5-Fluoropyrimidine (CAS 675-21-8) compounds, which shows good bioactivities for anti-cancer, antibacterial effects.

Diethyl fluoromalonate used in agricultural chemical industry
Diethyl fluoromalonate is an important intermediate for the synthesis of environment-friendly fungicide Fluoxastrobin developed by Bayer CropScience in 2005. Fluoxastrobin, commonly used in Fandango, Fortix, Scenic, DISARM, EVITO, and HEC 480 SC (trade names), is a new strobilurin fungicide active ingredient for the control of fungal diseases such as early blight, late blight, leaf spots, leaf rust, and Rhizoctonia solani.

Diethyl fluoromalonate for special materials
New functional fluorinated materials are rapidly emerging to meet the demanding requirements of advanced applications in fields as diverse as sensing, catalysis and environmental protection due to its excellent prosperities such as chemical resistance, heat endurance, dielectricity, noninflammability, non-stick?performance?and?wear-resistance. AS per Journal of Materials Chemistry, fluororesin,?fluoroelastomers, and fluorosilicone (FRS) are very popular fluoride-containing materials widely used in the fields of photoelectrons, fiber?optic, etc. Diethyl fluoromalonate can be used as the starting material for many of these specialty materials.

Diethyl fluoromalonate in synthesizing 4,5,6-Trifluoropyrimidine and dyestuff
More information is to be updated for the mechanism of action of diethyl fluoromalonate for the preparation of 4,5,6-Trifluoropyrimidine (CAS 17573-78-3). 4,5,6-Trifluoropyrimidine is an important pesticide intermediate and it is also applied as an intermediate dye industry.

Diethyl fluoromalonate in preparing enzyme?inhibitors
According to Wikipedia, fluoride salts are commonly used in biological assay processing to?inhibit?the activity of?phosphatases, such as?serine/threoninephosphatases. Fluoride mimics the?nucleophilic?hydroxide?ion in these enzymes' active sites.Beryllium fluoride?and?aluminium fluoride?are also used as phosphatase inhibitors, since these compounds are structural mimics of the?phosphate?group and can act as analogues of the?transition state?of the reaction. Diethyl fluoromalonate can be used to various synthesize enzyme inhibitors.

Diethyl fluoromalonate can also be used to prepare fluoride-containing amino acids, fluoride-containing Chalcone, fluorotetrahydroquinolines, and sedative areas.

Our advantages:

Environmental friendly and risk free
Our novel manufacturing process is much more environmental friendly than the traditional process. The traditional process emits HF which is extremely toxic and corrosive and a mixture of methylbenzene and triethylamine which are also toxic and difficult to contain. In contrast, our process does not involve any of these materials. Thus, our wastes can be easily treated and reach the emission standard.

Higher purity
Our diethyl fluoromalonate can reach as high as 99% purity (by GC), and is the highest assay that is commercially available. The common purity of diethyl fluoromalonate on the market is about 90% and it is difficult to further purify.

Bulk stock
As diethyl fluoromalonate is one of Banff’s most important products, a large stock is available all year round.
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• Diethyl fluoromalonate,CAS 685-88-1