Clotrimazole
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Molecular Structure
Detailed Description
Clotrimazole
Synonyms: (2-Chlorophenyl)diphenyl-1-imidazolylmethane;(Chlorotrityl)imidazole;1-((2-chlorophenyl)diphenylmethyl)-1h-imidazol;1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole;1-(o-chloro-alpha,alpha-diphenylbenzyl)-imidazol;1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazol;1-[alpha-(2-chlorophenyl)benzhydryl]imidazole
CAS: 23593-75-1
MF: C22H17ClN2
MW: 344.84
EINECS: 245-764-8
Product Categories: Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;Potassium channel;Aromatics;Heterocycles
Chemical Properties Crystalline
Usage Clotrimazole is an antifungal agent.
Test Items Specification Test Results
Character A white or pale yellow crystalline powder Complies
Solubility Practically insoluble in water,soluble in alcohol and in methylene chloride , slight soluble in ether. Complies
Identification IR spectrum Similar to the standard. Complies
Test TLC Principal spot of test solution is similar in position and size to the reference solution. Complies
Color test In the test , an orange colour develops becoming orange-brown. Complies
Melting point 141 to 145℃ 142.5 to 144℃
Appearance of solution BY6 Solution is clear and not more instensely coloured than reference solution BY6 Complies
(2-Chlorophenyl)diphenylmethanol Not more than 0.2% Complies
Imidazole Not more than 0.2% Complies
Loss on drying Not more than 0.5% 0.11%
Sulphated ash Not more than 0.1% 0.05%
Content Not less than 98.5% and not more than 100.5% 99.3%
Conclusion UP to the BP2004 standard.
- Clotrimazole