PF-562271 (besylate)

• Product NamePF-562271 (besylate)
  CAS No.939791-38-5
  Purity>98%
  Min Quantity
  Price~
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Detailed Description

PF-562271 (besylate)PF-562271 besylate is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

IC50 value: 1.5 nM(FAK); 14 nM(Pyk2) [1]

Target: PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region.

Target:Proteasome

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