Vismodegib

• Product NameVismodegib
  CAS No.879085-55-9
  Purity>98%
  Min Quantity
  Price~
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  Molecular Structure

Detailed Description

VismodegibVismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM.

IC50 value: 3 nM (hedgehog); 3.0 uM (P-gp) [1]

Target: hedgehog

in vitro: GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.

Target:Dopamine Receptor

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