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CAS No 92623-85-3 , (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

  • Name: (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
  • Synonyms: F 2207; (-)-milnacipran; Ixel;Midalcipran; Milnacipran (INN); Milnacipranum; Milnacipran [INN]; Toledomin;(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide; Milnacipranum [Latin];
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 228-228.5 deg C
  • Flash Point: 191.5°C
  • Boiling Point: 393°Cat760mmHg
  • Density: 1.077g/cm3
  • Refractive index: 1.553
  • Safety Statements: Hazard Codes XnRisk Statements 22RIDADR UN 2811 6.1/PG 3 WGK Germany 3 RTECS GZ1014010
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 191.5°C
  • Molecular Weight: 246.34798
  • InchiKey: GJJFMKBJSRMPLA-HIFRSBDPSA-N
  • InChI: InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/
    h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m1/s1
  • Risk Statements: 22
  • Molecular Formula: C15H22N2O
  • Molecular Structure:CAS No:92623-85-3 (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide

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92623-85-3 Milnacipran

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References of (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
Title: Milnacipran
CAS Registry Number: 92623-85-3
CAS Name: (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide
Synonyms: 1-phenyl-1-(diethylaminocarbonyl)-2-(aminomethyl)cyclopropane; midalcipran
Molecular Formula: C15H22N2O
Molecular Weight: 246.35
Percent Composition: C 73.13%, H 9.00%, N 11.37%, O 6.49%
Literature References: Serotonin and norepinephrine reuptake inhibitor (SNRI). Prepn: G. Mouzin et al., EP 68999; eidem, US 4478836 (1983, 1984 both to Pierre Fabre); B. Bonnaud et al., J. Med. Chem. 30, 318 (1987). Mechanism of action study: C. Moret et al., Neuropharmacology 24, 1211 (1985). Clinical inhibition of monoamine uptake: C. Palmier et al., Eur. J. Clin. Pharmacol. 37, 235 (1989). Review of pharmacology and clinical efficacy in depression: C. M. Spencer, M. I. Wilde, Drugs 56, 405-427 (1998).
 
Derivative Type: Hydrochloride
CAS Registry Number: 101152-94-7
Manufacturers' Codes: F-2207
Trademarks: Ixel (Fabre); Toledomin (Asahi)
Molecular Formula: C15H22N2O.HCl
Molecular Weight: 282.81
Percent Composition: C 63.70%, H 8.20%, N 9.91%, O 5.66%, Cl 12.54%
Properties: Crystals from ethanol-ethyl ether, mp 179-181°. LD50 orally in mice: 237 mg/kg (Bonnaud).
Melting point: mp 179-181°
Toxicity data: LD50 orally in mice: 237 mg/kg (Bonnaud)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Serotonin Noradrenaline Reuptake Inhibitor (SNRI); Serotonin Uptake Inhibitor.