Home > Name List By other > (6R,7R)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl) methyl]-8-oxo-5-thia-1-...

CAS No 82547-58-8 , (6R,7R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)
methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

  • Name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)
    methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Synonyms: (6R,7R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)
    methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; CFTM; Cefteram (INN); 82547-58-8; NCGC00183016-01; Cefterame; Ceftetrame; Cefteramum [Latin]; Ro 19-5247;Cefteramum;
  • CAS Registry Number:
  • Density: 1.95 g/cm3
  • Refractive index: 1.901
  • Molecular Weight: 479.49348
  • InchiKey: XSPUSVIQHBDITA-RKYNPMAHSA-N
  • InChI: InChI=1S/C16H17N9O5S2/c1-6-20-23-24(21-6)3-7-4-31-14-10(13(27)25(14)11
    (7)15(28)29)19-12(26)9(22-30-2)8-5-32-16(17)18-8/h5,10,14H,3-4H2,1-2H3,
    (H2,17,18)(H,19,26)(H,28,29)/b22-9-/t10-,14-/m1/s1
  • Molecular Formula: C16H17N9O5S2
  • Molecular Structure:CAS No:82547-58-8 (6R,7R)-7-[[(2Z)-2-(2-amino-1,<br />3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)<br />methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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References of (6R,7R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(5-methyltetrazol-2-yl)
methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Title: Cefteram
CAS Registry Number: 82547-58-8
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (+)-(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetamido]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-[2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetamido]-3-[2-(5-methyl-1,2,3,4-tetrazolyl)methyl]-D3-cephem-4-carboxylic acid; (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 72-(Z)-(O-methyloxime); ceftetrame
Manufacturers' Codes: Ro-19-5247; T-2525
Molecular Formula: C16H17N9O5S2
Molecular Weight: 479.49
Percent Composition: C 40.08%, H 3.57%, N 26.29%, O 16.68%, S 13.37%
Literature References: Third generation, orally active cephalosporin antibiotic. Prepn: BE 890499; H. Sadaki et al., US 4489072 (1982, 1984 both to Toyama). In vitro antibacterial activity: R. Wise et al., Antimicrob. Agents Chemother. 29, 1067 (1986); in vitro activity vs Neisseria gonorrhoeae: W. R. Bowie et al., ibid. 31, 470 (1987). General pharmacology in animals: S. Hirai et al., Jpn. J. Antibiot. 39, 958 (1986), C.A. 105, 183450a (1986). Pharmacokinetics and tissue distribution in animals: I. Saikawa et al., ibid. 979, C.A. 105, 183338v (1986). Series of articles on activity, toxicology, pharmacology and clinical efficacy: Chemotherapy (Tokyo) 34, Suppl. 2, 1-984 (1986). Acute toxicity: S. Sato et al., ibid. 166.
Properties: Crystals from acetone, mp >200°.
Melting point: mp >200°
 
Derivative Type: Pivaloyloxymethyl ester
CAS Registry Number: 82547-81-7
Synonyms: Cefteram pivoxil
Manufacturers' Codes: T-2588
Trademarks: Tomiron (Toyama)
Molecular Formula: C22H27N9O7S2
Molecular Weight: 593.64
Percent Composition: C 44.51%, H 4.58%, N 21.24%, O 18.87%, S 10.80%
Properties: Oral prodrug of cefteram. Crystals, mp 127-128° (dec). LD50 in male, female mice, rats (g/kg): >6.00, 5.86, 5.63, 5.09 i.p.; in both species >6.00 s.c.; in male mice, rats, dogs (g/kg): >6.00, >6.00, >2.00 orally (Sato).
Melting point: mp 127-128° (dec)
Toxicity data: LD50 in male, female mice, rats (g/kg): >6.00, 5.86, 5.63, 5.09 i.p.; in both species >6.00 s.c.; in male mice, rats, dogs (g/kg): >6.00, >6.00, >2.00 orally (Sato)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.