Home > Name List By other > (6R)-7-[[(2Z)-2-(2-amino-1, 3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1, 3-thiazol-5-yl)ethenyl]-8-oxo-5...

CAS No 104145-95-1 , (6R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,
3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid

  • Name: (6R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,
    3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid
  • Synonyms: 104145-95-1; C19H18N6O5S3; LS-171904;Cefditoren [USAN:INN];(6R)-7-[[(2Z)-2-(2-amino-1,
    3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,
    3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.75g/cm3
  • Refractive index: 1.825
  • Flash Point: °C
  • Molecular Weight: 506.57842
  • InchiKey: KMIPKYQIOVAHOP-JZYNXJEQSA-N
  • InChI: InChI=1S/C19H18N6O5S3/c1-8-11(33-7-21-8)4-3-9-5-31-17-13(16(27)25(17)14
    (9)18(28)29)23-15(26)12(24-30-2)10-6-32-19(20)22-10/h3-4,6-7,13,17H,5H2,
    1-2H3,(H2,20,22)(H,23,26)(H,28,29)/b4-3-,24-12-/t13?,17-/m1/s1
  • Molecular Formula: C19H18N6O5S3
  • Molecular Structure:CAS No:104145-95-1 (6R)-7-[[(2Z)-2-(2-amino-1,<br />3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,<br />3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-<br />carboxylic acid

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104145-95-1 CEFDITOREN PIVOXIL

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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104145-95-1 Cefditoren

  • India Manus Aktteva null
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, null,nullIndia
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104145-95-1 Cefditoren

  • China YST PHARM [Manufacturers]
  • Tel: 86-311-85322916
  • Fax: 86-311-85322918
  • Address: No.266 Tianshan Street Hi-Tech District Shijiazhuang, China Shijiazhuang,HebeiChina
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104145-95-1 Cefditoren

  • China Zhejiang Huafang Pharmaceutical Co., Ltd [Manufacturers]
  • Tel: +86-576-84172638,
  • Fax: +86-576-84179781
  • Address: 10 Dazha Road, Light Industry and Chemical Industry Investment Area (Jiangkou), Huangyan Economic Development Zone, Zhejiang, China 318020 Huangyan,ZhejiangChina
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104145-95-1 Cefditoren

  • China NINGBO SINOVA I/E CORP. [Importer/Exporter]
  • Tel: +86-574-5500-1566/77
  • Fax: +86-574-87302450 55001588
  • Address: Rm 1206 Kaifeng bldg, No. 762, Zhongxing Rd., Jiangdong, Ningbo, China null,ZhejiangChina
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104145-95-1 CEFDITOREN PIVOXIL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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    (N)Nanjing 210009,China null,nullChina
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1/1
References of (6R)-7-[[(2Z)-2-(2-amino-1,
3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(Z)-2-(4-methyl-1,
3-thiazol-5-yl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid
Title: Cefditoren
CAS Registry Number: 104145-95-1
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(1Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-[(Z)-2-(4-methyl-5-thiazolyl)vinyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 72-(Z)-(O-methyloxime)
Manufacturers' Codes: ME-1206
Molecular Formula: C19H18N6O5S3
Molecular Weight: 506.58
Percent Composition: C 45.05%, H 3.58%, N 16.59%, O 15.79%, S 18.99%
Literature References: Broad spectrum, third generation cephalosporin; active metabolite of orally absorbed pivaloyloxymethyl ester prodrug. Prepn: K. Atsumi et al., EP 175610; eidem, US 4839350 (1986, 1989 both to Meiji); K. Sakagami et al., J. Antibiot. 43, 1047 (1990); idem et al., Chem. Pharm. Bull. 39, 2433 (1991). In vitro and in vivo activities: A. Tamura et al., Antimicrob. Agents Chemother. 32, 1421 (1988). Extensive in vitro activity study: D. Felmingham et al., Drugs Exp. Clin. Res. 20, 127 (1994). Clinical pharmacokinetics and efficacy in pediatrics: N. Iwai et al., Jpn. J. Antibiot. 47, 181 (1994), C.A. 120, 260636e (1994).
 
Derivative Type: Sodium salt, sesquihydrate
Molecular Formula: C19H17N6NaO5S3.1?H2O
Molecular Weight: 537.57
Percent Composition: C 42.45%, H 3.37%, N 15.63%, Na 4.28%, O 16.37%, S 17.89%
Properties: Pale yellow crystals from water, mp 195-200° (dec). [a]D20 +121.6° (c = 0.5 in methanol).
Melting point: mp 195-200° (dec)
Optical Rotation: [a]D20 +121.6° (c = 0.5 in methanol)
 
Derivative Type: Pivaloyloxymethyl ester
CAS Registry Number: 117467-28-4
Synonyms: Cefditoren pivoxil
Manufacturers' Codes: ME-1207
Trademarks: Meiact (Meiji Seika)
Molecular Formula: C25H28N6O7S3
Molecular Weight: 620.72
Percent Composition: C 48.37%, H 4.55%, N 13.54%, O 18.04%, S 15.50%
Properties: Pale yellow powder, mp 127-129°. [a]D20 -48.5° (c = 0.5 in methanol).
Melting point: mp 127-129°
Optical Rotation: [a]D20 -48.5° (c = 0.5 in methanol)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.