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CAS No 81525-10-2 , (6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate

  • Name: (6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate
  • Synonyms: Nafamostatum [Latin]; 81525-10-2; Nafamstat Mesilate;Nafamostat [INN];(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; 6-Amidino2-naphthyl 4-guanidinobenzoate; Nafamostat (INN);
  • CAS Registry Number:
  • Flash Point: 339.1°C
  • Boiling Point: 637.2°C at 760 mmHg
  • Density: 1.39g/cm3
  • Refractive index: 1.694
  • Flash Point: 339.1°C
  • Molecular Weight: 347.37058
  • InchiKey: MQQNFDZXWVTQEH-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)
    11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
  • Molecular Formula: C19H17N5O2
  • Molecular Structure:CAS No:81525-10-2 (6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate

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References of (6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate
Title: Nafamostat
CAS Registry Number: 81525-10-2
CAS Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester
Synonyms: 6-amidino-2-naphthyl-4-guanidinobenzoate; nafamstat
Molecular Formula: C19H17N5O2
Molecular Weight: 347.37
Percent Composition: C 65.69%, H 4.93%, N 20.16%, O 9.21%
Literature References: Non-peptide protease inhibitor. Prepn: S. Fujii et al., EP 48433; eidem, US 4454338 (1982, 1984 both to Torii & Co.); T. Aoyama et al., Chem. Pharm. Bull. 33, 1458 (1985). Inhibitory effects on trypsin, thrombin, kallikrein, plasmin and complement-mediated hemolysis: S. Fujii, Y. Hitomi, Biochim. Biophys. Acta 661, 342 (1981); T. Aoyama et al., Jpn. J. Pharmacol. 35, 203 (1984). Effect in experimental acute pancreatitis in rats: M. Iwaki et al., ibid. 41, 155 (1986). Spectrofluorometric determn in biological material: T. Aoyama et al., Chem. Pharm. Bull. 33, 2142 (1985). Clinical anti-complement activity: Y. Miyamoto et al., Trans. Am. Soc. Artif. Intern. Organs 31, 508 (1985).
 
Derivative Type: Dimethanesulfonate
CAS Registry Number: 82956-11-4
Synonyms: Nafamostat mesylate
Manufacturers' Codes: FUT-175
Trademarks: Futhan (Torii)
Molecular Formula: C19H17N5O2.2CH3SO3H
Molecular Weight: 539.58
Percent Composition: C 46.74%, H 4.67%, N 12.98%, O 23.72%, S 11.89%
Properties: Crystals from ethyl ether, mp 217-220° (Fujii). Also reported as colorless powder from water, mp 260° (dec) (Aoyama).
Melting point: mp 217-220° (Fujii); mp 260° (dec) (Aoyama)
 
Therap-Cat: Enzyme inhibitor (protease).
Keywords: Protease Inhibitor.