Home > Name List By other > [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate

CAS No 59721-28-7 , [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]
4-(diaminomethylideneamino)benzoate

  • Name: [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]
    4-(diaminomethylideneamino)benzoate
  • Synonyms: 59721-28-7;Camostatum [INN-Latin]; Camostat (INN); CCRIS 7219;[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]
    4-(diaminomethylideneamino)benzoate; Camostat [INN]; FOY-305; camostate; foypan;
  • CAS Registry Number:
  • Density: 1.28 g/cm3
  • Refractive index: 1.596
  • Molecular Weight: 398.41248
  • InchiKey: XASIMHXSUQUHLV-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19
    (27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23)
  • Molecular Formula: C20H22N4O5
  • Molecular Structure:CAS No:59721-28-7 [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]<br />4-(diaminomethylideneamino)benzoate

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59721-28-7 CAMOSTAT MESILATE

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59721-28-7 Benzeneacetic acid,4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]-, 2-(dimethylamino)-2-oxoethylester

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References of [4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]
4-(diaminomethylideneamino)benzoate
Title: Camostat
CAS Registry Number: 59721-28-7
CAS Name: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester
Synonyms: N,N-dimethylcarbamoylmethyl-p-(p-guanidinobenzoyloxy)phenylacetate
Molecular Formula: C20H22N4O5
Molecular Weight: 398.41
Percent Composition: C 60.29%, H 5.57%, N 14.06%, O 20.08%
Literature References: Orally active, non-peptide proteolytic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate, q.v. Prepn: S. Fujii et al., DE 2548886; eidem, US 4021472 (1976, 1977 both to Ono). Enzyme inhibition study: Y. Tamura et al., Biochim. Biophys. Acta 484, 417 (1977). Inhibition of exptl tumors in mice: M. Ohkoshi, Gann 72, 959 (1981), C.A. 96, 97304v (1982); M. Ohkoshi, S. Fujii, ibid. 73, 108 (1982), C.A. 96, 155182s (1982). Prevention of acute exptl pancreatitis: S. Takasugi et al., Digestion 24, 36 (1982). Absorption and excretion: S. Hiraku et al., Iyakuhin Kenkyu 13, 756 (1982), C.A. 97, 120038t (1982).
 
Derivative Type: Methanesulfonate
CAS Registry Number: 59721-29-8
Synonyms: Camostat mesylate
Manufacturers' Codes: FOY-305
Trademarks: Foipan (Ono)
Molecular Formula: C20H22N4O5.CH3SO3H
Molecular Weight: 494.52
Percent Composition: C 51.00%, H 5.30%, N 11.33%, O 25.88%, S 6.48%
Properties: Solid from methanol/ether, mp 150-155°. Sol in water.
Melting point: mp 150-155°
 
Therap-Cat: Protease inhibitor.
Keywords: Protease Inhibitor.