Home > Name List By 6 > 6, 8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline- 3-carboxylic acid China

CAS No 79660-72-3 , 6,
8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-
3-carboxylic acid Search by region : China

  • Name: 6,
    8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-
    3-carboxylic acid
  • Synonyms: Fleroxicin; 79660-72-3; AM 833; Megalocin;Megalone; Fleroxacinum; Quinodis; AM-833; Fleroxacino;6,
    8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-
    3-carboxylic acid;
  • CAS Registry Number:
  • Density: 1.409g/cm3
  • Refractive index: 1.568
  • Molecular Weight: 369.33833
  • InchiKey: XBJBPGROQZJDOJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23
    (3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
  • Molecular Formula: C17H18F3N3O3
  • Molecular Structure:CAS No:79660-72-3 6,<br />8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-<br />3-carboxylic acid

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References of 6,
8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-
3-carboxylic acid
Title: Fleroxacin
CAS Registry Number: 79660-72-3
CAS Name: 6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Manufacturers' Codes: AM-833; Ro-23-6240
Trademarks: Megalocin (Roche); Megalone (Roche); Quinodis (Roche)
Molecular Formula: C17H18F3N3O3
Molecular Weight: 369.34
Percent Composition: C 55.28%, H 4.91%, F 15.43%, N 11.38%, O 13.00%
Literature References: Fluorinated quinolone antibacterial. Prepn: BE 887574; T. Irikura et al., US 4398029 (1981, 1983 both to Kyorin). Antibacterial spectrum in vitro and in vivo: K. Hirai et al., Antimicrob. Agents Chemother. 29, 1059 (1986). In vitro activity vs anaerobic bacteria: J. Wüst, U. Hardegger, Eur. J. Clin. Microbiol. 6, 688 (1987). HPLC determn in biological fluids: H. Kusajima et al., J. Chromatogr. 381, 137 (1986). Pharmacokinetics and bioavailability: E. Weidekamm et al., Antimicrob. Agents Chemother. 31, 1909 (1987). Preliminary clinical evaluation in gonorrhea: J. B. J. Boerema et al., J. Antimicrob. Chemother. 21, 140 (1988).
 
Derivative Type: Hydrochloride
Molecular Formula: C17H18F3N3O3.HCl
Molecular Weight: 405.80
Percent Composition: C 50.32%, H 4.72%, F 14.05%, N 10.35%, O 11.83%, Cl 8.74%
Properties: Crystals from water, mp 269-271° (dec).
Melting point: mp 269-271° (dec)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.