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CAS No 79455-30-4 , N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide

  • Name: N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide
  • Synonyms: 79455-30-4; 1,2-Bis(nicotinamido)propane;Nicaravenum [INN-Latin]; N,N'-Propylenenicotinamide; CCRIS 7280;N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide;
  • CAS Registry Number:
  • Density: 1.213 g/cm3
  • Refractive index: 1.584
  • Molecular Weight: 284.31314
  • InchiKey: KTXBOOWDLPUROC-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-
    6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)
  • Molecular Formula: C15H16N4O2
  • Molecular Structure:CAS No:79455-30-4 N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide

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References of N-[2-(pyridine-3-carbonylamino)propyl]pyridine-3-carboxamide
Title: Nicaraven
CAS Registry Number: 79455-30-4
CAS Name: N,N￠-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
Synonyms: 1,2-bis(nicotinamido)propane; (±)-N,N￠-propylenedinicotinamide; AVS
Trademarks: Antevas (Chugai)
Molecular Formula: C15H16N4O2
Molecular Weight: 284.31
Percent Composition: C 63.37%, H 5.67%, N 19.71%, O 11.25%
Literature References: Hydroxyl radical scavenger. Prepn: T. Mori et al., EP 29602; eidem, US 4366161 (1981, 1982 both to Chugai); T. Doi et al., Synlett 1999, 1751. Effect on human platelet aggregation: T. Komiya et al., Clin. Neuropharmacol. 22, 11 (1999). Clinical trial in subarachnoid hemorrhage: T. Asano et al., J. Neurosurg. 84, 792 (1996). Review: K. K. Jain, Expert Opin. Invest. Drugs 9, 859-870 (2000).
Properties: Crystals from ethyl acetate, mp 156-157°. Sol in water.
Melting point: mp 156-157°
Therap-Cat: In treatment of vasospasm following subarachnoid hemorrhage.