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CAS No 75847-73-3 , Enalapril

  • Name: Enalapril
  • Synonyms: Enalapril;Amprace; Vasotec; Vaseretic;(S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline; 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester; Renitec;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 143-144.5 deg C
  • Density: 1.204g/cm3
  • Refractive index: 1.549
  • Water Solubility: sparingly soluble (freely in methanol, soluble in ethanol)
  • Safety Statements: S22;S24/25
  • Hazard Symbols: UN NO.
  • Molecular Weight: 376.45
  • InChI: InChI=1/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16+,17-/m0/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C20H28N2O5
  • Molecular Structure:CAS No:75847-73-3 Enalapril

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75847-73-3 ENALAPRIL

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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75847-73-3 Enalapril

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75847-73-3 Enalapril

  • IUPAC NAME-(2S)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]pyrrolidine-2-carboxylic acid (Diagrams above are enalapril and enalaprilat, respectively. Data below refers to enalapril unless indicated) MOLECULAR FORMULA-C20H28N2O...
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75847-73-3 Enalapril

  • Enalapril
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
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75847-73-3 Enalapril

  • China YiPeng Chemical [Manufacturers]
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75847-73-3 Enalapril

  • China Ningbo Inno Pharmchem Co., Ltd. [Manufacturers]
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75847-73-3 Enalapril

  • United States Waterstone Technology LLC [Manufacturer]
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75847-73-3 ENALAPRIL BP

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References of Enalapril
Title: Enalapril
CAS Registry Number: 75847-73-3
CAS Name: N-[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline
Synonyms: 1-[N-[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]-L-proline 1￠-ethyl ester
Molecular Formula: C20H28N2O5
Molecular Weight: 376.45
Percent Composition: C 63.81%, H 7.50%, N 7.44%, O 21.25%
Literature References: Angiotensin-converting enzyme (ACE) inhibitor; de-esterified in vivo to its active diacid metabolite, enalaprilat, q.v. Prepn: A. A. Patchett et al., Nature 288, 280 (1980); eidem, EP 12401; E. E. Harris et al., US 4374829 (1980, 1983 both to Merck & Co.). Pharmacology: D. M. Gross et al., J. Pharmacol. Exp. Ther. 216, 552 (1981); C. S. Sweet et al., ibid. 558. Bioavailability and metabolism: E. H. Ulm, Drug Metab. Rev. 14, 99 (1983). Comprehensive description: D. P. Ip, G. S. Brenner, Anal. Profiles Drug Subs. 16, 207-243 (1987). Clinical trial in congestive heart failure: Consensus Trial Study Group, N. Engl. J. Med. 316, 1429 (1987). Review of clinical experience in hypertension: H. J. Gomez et al., J. Cardiovasc. Pharmacol. 15, Suppl. 3, S26-S29 (1990); of clinical pharmacokinetics: R. J. MacFadyen et al., Clin. Pharmacokinet. 25, 274-282 (1993); of combination with hydrochlorothiazide: P. L. Malini, Adv. Ther. 10, 253-262 (1993).
 
Derivative Type: Maleate
CAS Registry Number: 76095-16-4
Manufacturers' Codes: MK-421
Trademarks: Amprace (Merck & Co.); Cardiovet (Intervet); Enacard (Merial); Enapren (Merck & Co.); Glioten (Armstrong); Hipoartel (Ipsen); Innovace (Merck & Co.); Naprilene (Sigma-Tau); Pres (Boehringer, Ing.); Renitec (Merck & Co.); Reniten (Merck & Co.); Renivace (Merck & Co.); Vasotec (Merck & Co.); Xanef (Merck & Co.)
Molecular Formula: C20H28N2O5.C4H4O4
Molecular Weight: 492.52
Percent Composition: C 58.53%, H 6.55%, N 5.69%, O 29.24%
Properties: White to off-white crystalline powder, mp 143-144.5°. Soly (g/ml): water 0.025; alcohol 0.08; methanol 0.20. [a]D25 -42.2° (c = 1 in methanol). pH (1% water) 2.6. pKa1 3.0; pKa2 (25°) 5.4.
Melting point: mp 143-144.5°
pKa: pKa1 3.0; pKa2 (25°) 5.4
Optical Rotation: [a]D25 -42.2° (c = 1 in methanol)
 
Derivative Type: Mixture of maleate with hydrochlorothiazide
Trademarks: Acesistem (Sigma-Tau); Co-Renitec (Merck & Co.); Enaloc (Leiras); Innozide (Merck & Co.); Lotrial D (Roemmers); Renacor (Merck & Co.); Vaseretic (Merck & Co.); Vasoretic (Merck & Co.); Xynertec (Merck & Co.)
 
Therap-Cat: Antihypertensive.
Therap-Cat-Vet: In treatment of heart failure in dogs.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.