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CAS No 75706-12-6 , 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

  • Name: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
  • Synonyms: HWA-486; Leflunomidum; lefunamide;Arava; Leflunomidum [INN-Latin]; HWA 486; 75706-12-6;5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomid; Leflunomida;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 163-168 ºC
  • Density: 1.392 g/cm3
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 270.20727
  • InchiKey: VHOGYURTWQBHIL-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,
    14)15/h2-6H,1H3,(H,17,18)
  • Risk Statements: S26
  • Molecular Formula: C12H9F3N2O2
  • Molecular Structure:CAS No:75706-12-6 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
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75706-12-6 Leflunomide

  • Leflunomide Cas No: 75706-12-6 White Or Off- White Crystalline Powder Assay:98%-102% Usage: Antirheumatic For more details please contact us. Emily Liu Cangzhou Goldlion Chemicals Co., Ltd Add: 402-1, No.5th Building, Chaoyang Huayuan Area ,NO.32, Yu...
  • China Cangzhou Goldlion Chemicals Co., Ltd [Manufacturer]
  • Tel: 86-317-5698010
  • Fax: 86-317-5304268
  • Address: 2201-A-1, Jinding Manor, Cangzhou ,HebeiChina

75706-12-6 Leflunomide

  • Leflunomide; Leflunomide is an isoxazole immunomodulator with anti-proliferative activity. Its mechanism of action is mainly to inhibit the activity of dihydroorotate dehydrogenase and thus affect the pyrimidine synthesis of activated lymphocytes.
  • China Foshan DaoLin Biotechnology Co., Ltd. [Agent]
  • Tel: 86-0757-86287543
  • Address: Third Building,Vanke Gold Area Plaza, Nanhai District Foshan,GuangdongChina
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75706-12-6 Leflunomide

  • Product Name: Leflunomide Synonyms: LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLU...
  • Min. Order: 500
  • FOB Price: USDfalse - false /
  • China Wuhan Hezhong Bio-Chemical Manufature Co.,Ltd [Manufacturer]
  • Tel: 86-27-50756046
  • Address: Zhongshan Road No 496 Wuhan,HubeiChina
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75706-12-6 Leflunomide

  • Product Name: Leflunomide Synonyms: LEFLUNOMIDE;HWA 486;ALPHA,ALPHA,ALPHA-TRIFLUORO-5-METHYL-4-ISOXAZOLECARBOXY-P-TOLUIDIDE;5-METHYLISOXAZOLE-4-(4-TRIFLUOROMETHYLCARBOXANILIDE);5-METHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]-4-ISOXAZOLECARBOXAMIDE;N-(4-TRIFLU...
  • Min. Order: 500
  • FOB Price: USDfalse - false /
  • China Wuhan Yuancheng Gongchuang Technology Co.Ltd. [Manufacturer]
  • Tel: 86-27-50756064
  • Address: No.496,Zhongshan Road, Wuhan, Hubei, China Wuhan,HubeiChina
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75706-12-6 Leflunomide

  • Leflunomide Synonyms:LEFLUNOMIDE;HWA 486; CAS:75706-12-6 Appearance:Off White Crystalline Solid Purity:99% Package:25kg/cardboard MF:C12H9F3N2O2 MW:270.21 mp:163-168°C Usage:An immunosuppressive. Inhibits T and B cell proliferation. Activity is attri...
  • Min. Order: 10
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  • China Raw Steroid Main Shop [Manufacturer]
  • Tel: 86-0731-22290207
  • Fax: --
  • Address: Hunan zhuzhou,HunanChina
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75706-12-6 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

  • 5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide
  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
    +49 (32 12) 1 00 74 76
  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany ,Germany
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75706-12-6 leflunomide

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75706-12-6 leflunomide

  • United States HBCChem, Inc. [Manufacturers]
  • Tel: +1-510-219-6317
  • Fax: +1-510-675-0318
  • Address: Union City,CaliforniaUnited States
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75706-12-6 Leflunomide

  • Leflunomide
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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75706-12-6 Leflunomide

  • IUPAC NAME-5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide MOLECULAR FORMULA-C12H9F3N2O2 MOLAR MASS-270.207 g/mol Leflunomide is a disease-modifying antirheumatic drug used in active moderate to severe rheumatoid arthritis and psoriat...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641875
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

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References of 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Title: Leflunomide
CAS Registry Number: 75706-12-6
CAS Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Synonyms: a,a,a-trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 5-methylisoxazole-4-carboxylic acid trifluoromethylanilide
Manufacturers' Codes: HWA-486
Trademarks: Arava (Sanofi-Aventis)
Molecular Formula: C12H9F3N2O2
Molecular Weight: 270.21
Percent Composition: C 53.34%, H 3.36%, F 21.09%, N 10.37%, O 11.84%
Literature References: Disease modifying antirheumatic drug (DMARD) with immunosuppressant activity. Converted in vivo to its active open ring metabolite, teriflunomide, q.v. Inhibits de novo pyrimidine biosynthesis in immune cells. Prepn: F. J. Kaemmerer, R. Schleyerbach, DE 2854439; eidem, US 4284786 (1980, 1981 both to Hoechst); and pharmacology: P. Fossa et al., Farmaco 46, 789 (1991). HPLC determn of active metabolite in plasma: V. C. Dias et al., Ther. Drug Monit. 17, 84 (1995). Review of mechanisms of action: R. I. Fox, J. Rheumatol. 25, Suppl. 53, 20-26 (1998); of clinical pharmacology: B. Rozman, ibid. 27-32. Clinical trial in rheumatoid arthritis: V. Strand et al., Arch. Intern. Med. 159, 2542 (1999). Reviews: C. Miceli-Richard, M. Dougados, Expert Opin. Pharmacother. 4, 987-997 (2003); J. P. Kaltwasser, F. Behrens, ibid. 6, 787-801 (2005).
Properties: Crystals from toluene, mp 166.5°. pKa 10.8. Soly in water (25°): 25 - 27 mg/l. Sol in methanol, ethanol, acetone.
Melting point: mp 166.5°
pKa: pKa 10.8
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic; Immunomodulator.