Home > Name List By 5 > 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

CAS No 75706-12-6 , 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

  • Name: 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
  • Synonyms: HWA-486; Leflunomidum; lefunamide;Arava; Leflunomidum [INN-Latin]; HWA 486; 75706-12-6;5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomid; Leflunomida;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 163-168 ºC
  • Density: 1.392 g/cm3
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Molecular Weight: 270.20727
  • InchiKey: VHOGYURTWQBHIL-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,
    14)15/h2-6H,1H3,(H,17,18)
  • Risk Statements: S26
  • Molecular Formula: C12H9F3N2O2
  • Molecular Structure:CAS No:75706-12-6 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

Related products

Search by region :

Select to

75706-12-6 alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidine

  • alfa-alfa-alfa-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidineLeflunomide, 99.5% Min.
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
Contact Supplier

75706-12-6 LEFLUNOMIDE

  • LEFLUNOMIDE
  • United States INTERNATIONAL LABORATORY LIMITED [Manufacturer]
  • Tel: ( 650 ) 278-9963
  • Fax: ( 650 ) 589-2786
  • Address: 1067 SNEATH LN SAN BRUNO CA 94066, USA SAN BRUNOUNITED STATES SAN BRUNO,nullUnited States
Contact Supplier

75706-12-6 Leflunomide

  • Leflunomide
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
Contact Supplier

75706-12-6 Leflunomide

  • Leflunomide
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,nullUnited States
Contact Supplier

75706-12-6 Leflunomide

  • Leflunomide
  • China Shenzhen sailing chemical Co.,Ltd [Manufacturer]
  • Tel: 86-755-26415005
  • Fax: 86-755-26412646
  • Address: 1-403 Bei tou hao yuan Nanxing Road Nanshan District Shenzhen, Guangdong 518051 shenzhenCHINA shenzhen,nullChina
Contact Supplier

75706-12-6 Serrapeptase

  • Serrapeptase, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

75706-12-6 Leflunomide

  • Leflunomide, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
Contact Supplier

75706-12-6 leflunomide

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
Contact Supplier

75706-12-6 Leflunomide

  • Leflunomide
  • Germany Paragos [Manufacturer]
  • Tel: +49 69 41 09 21 91
  • Fax: +49 69 42 69 45 85
  • Address: Alt Fechenheim 3460386 Frankfurt/MainGERMANY Frankfurt/Main,nullGermany
Contact Supplier

75706-12-6 N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide

  • N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
  • France Interchim S.A. [Importer/Exporter]
  • Tel: (33) 4 70 03 88 55
  • Fax: (33) 4 70 03 82 60
  • Address: 211, AVENUE, J.F. KENNEDY, MONTLUCON - 03100, ALLIER, FRANCE null,nullFrance
Contact Supplier

Select to

2/12
Previous 1 2 3 4 5 6 7 8 9 10 Next
References of 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
Title: Leflunomide
CAS Registry Number: 75706-12-6
CAS Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Synonyms: a,a,a-trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 5-methylisoxazole-4-carboxylic acid trifluoromethylanilide
Manufacturers' Codes: HWA-486
Trademarks: Arava (Sanofi-Aventis)
Molecular Formula: C12H9F3N2O2
Molecular Weight: 270.21
Percent Composition: C 53.34%, H 3.36%, F 21.09%, N 10.37%, O 11.84%
Literature References: Disease modifying antirheumatic drug (DMARD) with immunosuppressant activity. Converted in vivo to its active open ring metabolite, teriflunomide, q.v. Inhibits de novo pyrimidine biosynthesis in immune cells. Prepn: F. J. Kaemmerer, R. Schleyerbach, DE 2854439; eidem, US 4284786 (1980, 1981 both to Hoechst); and pharmacology: P. Fossa et al., Farmaco 46, 789 (1991). HPLC determn of active metabolite in plasma: V. C. Dias et al., Ther. Drug Monit. 17, 84 (1995). Review of mechanisms of action: R. I. Fox, J. Rheumatol. 25, Suppl. 53, 20-26 (1998); of clinical pharmacology: B. Rozman, ibid. 27-32. Clinical trial in rheumatoid arthritis: V. Strand et al., Arch. Intern. Med. 159, 2542 (1999). Reviews: C. Miceli-Richard, M. Dougados, Expert Opin. Pharmacother. 4, 987-997 (2003); J. P. Kaltwasser, F. Behrens, ibid. 6, 787-801 (2005).
Properties: Crystals from toluene, mp 166.5°. pKa 10.8. Soly in water (25°): 25 - 27 mg/l. Sol in methanol, ethanol, acetone.
Melting point: mp 166.5°
pKa: pKa 10.8
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic; Immunomodulator.