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CAS No 72956-09-3 , 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

  • Name: 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
  • Synonyms: 72956-09-3; Dilatrend; Kredex; Eucardic; Querto;1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; Coropress; Carvedilolum; Carvedilolum [Latin];Coreg;
  • CAS Registry Number:
  • Transport: UN 3077 9/PG 3
  • Melting Point: 113-117 ºC
  • Density: 1.25 g/cm3
  • Safety Statements: 61-36-26
  • Hazard Symbols: N: Dangerous for the environment;Xn: Harmful;
  • Molecular Weight: 406.47424
  • InchiKey: OGHNVEJMJSYVRP-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-
    23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
  • Risk Statements: 51/53-36/37/38-20/21/22
  • Molecular Formula: C24H26N2O4
  • Molecular Structure:CAS No:72956-09-3 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

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References of 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
Title: Carvedilol
CAS Registry Number: 72956-09-3
CAS Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Manufacturers' Codes: BM-14190; DQ-2466
Trademarks: Coreg (GSK); Dilatrend (Roche); Dimitone (Erco); Eucardic (Roche); Kredex (GSK); Querto (Byk Gulden)
Molecular Formula: C24H26N2O4
Molecular Weight: 406.47
Percent Composition: C 70.92%, H 6.45%, N 6.89%, O 15.74%
Literature References: Nonselective b-adrenergic blocker with a1-blocking activity. Prepn: F. Wiedemann et al., DE 2815926; eidem, US 4503067 (1979, 1985 both to Boehringer Mannheim). General pharmacological profile: M. Hirohashi et al., Arzneim.-Forsch. 40, 735 (1990). HPLC determn in biological fluids: K. Reiff, J. Chromatogr. 413, 355 (1987). Series of articles on clinical pharmacology and efficacy in hypertension: J. Cardiovasc. Pharmacol. 19, Suppl. 1, S1-S146 (1992). Clinical trial in chronic heart failure: M. Packer et al., N. Engl. J. Med. 334, 1349 (1996). Review: W. H. Frishman, ibid. 339, 1759-1765 (1998).
Properties: Colorless crystals from ethyl acetate, mp 114-115°. Freely sol in DMSO; sol in methylene chloride, methanol; sparingly sol in ethanol, isopropanol; slightly sol in ethyl ether. Practically insol in water.
Melting point: mp 114-115°
Therap-Cat: Antihypertensive; in treatment of congestive heart failure.
Keywords: ?Adrenergic Blocker; Antihypertensive; Aryloxypropanolamine Derivatives.