Title: Guaifenesin
CAS Registry Number: 93-14-1
CAS Name: 3-(2-Methoxyphenoxy)-1,2-propanediol
Synonyms: glycerol mono(2-methoxyphenyl) ether; glycerol a-(2-methoxyphenyl) ether; guaiacyl glyceryl ether; glyceryl guaiacyl ether; glycerol guaiacolate; a-glyceryl guaiacol ether;
o-methoxyphenyl glyceryl ether; 1,2-dihydroxy-3-(2-methoxyphenoxy)propane; guaiacol glyceryl ether; guaiphenesin; guaiacuran
Manufacturers' Codes: MY-301; XL-90
Trademarks: Colrex (Solvay); Mucinex (Adams); Myoscain (Sanochemia); Relaxil G (Pannon); Resyl (Novartis); Robitussin (Wyeth)
Molecular Formula: C10H14O4
Molecular Weight: 198.22
Percent Composition: C 60.59%, H 7.12%, O 32.29%
Literature References: Centrally acting muscle relaxant with expectorant properties. Prepn: Marle,
J. Chem. Soc. 101, 305 (1912); Yale
et al., J. Am. Chem. Soc. 72, 3710 (1950); Roviralta, Astoul,
ES 212920 (1954),
C.A. 49, 8332b (1955). Prepn from 2-methoxyphenol and glycidol: W. Merk
et al., DE 3106995;
eidem, US 4390732 (1982, 1983 to Degussa AG). GLC determn in blood: W. R. Maynard, R. B. Bruce,
J. Pharm. Sci. 59, 1346 (1970). Clinical use in chronic respiratory disease: D. G. Workman
et al., Curr. Ther. Res. 7, 665 (1965). Clinical efficacy as antitussive: J. J. Kuhn
et al., Chest 82, 713 (1982). Pharmacokinetics and cardiopulmonary effects in horses: J. A. E. Hubbell
et al., Am. J. Vet. Res. 41, 1751 (1980). Use in equine anesthesia: J. L. Grandy, W. N. McDonell,
J. Am. Vet. Med. Assoc. 176, 619 (1980); G. J. Brouwer,
Equine Vet. J. 17, 133 (1985).
Properties: Minute rhombic prisms from ether, mp 78.5-79°. bp19 215°. Slightly bitter aromatic taste. One gram dissolves in 20 ml water at 25°. Much more sol in hot water; freely sol in ethanol; sol in chloroform, glycerol, propylene glycol, DMF; moderately sol in benzene. Practically insol in petr ether.
Melting point: mp 78.5-79°
Boiling point: bp19 215°
Therap-Cat: Expectorant
Therap-Cat-Vet: Expectorant; muscle relaxant.
Keywords: Expectorant.
