Title: Nicorandil
CAS Registry Number: 65141-46-0
CAS Name: N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Synonyms: N-(2-hydroxyethyl)nicotinamide nitrate (ester)
Manufacturers' Codes: SG-75
Trademarks: Adancor (Merck-Cl¢enot); Ikorel (RPR); Perisalol (Chugai); Sigmart (Chugai)
Molecular Formula: C8H9N3O4
Molecular Weight: 211.17
Percent Composition: C 45.50%, H 4.30%, N 19.90%, O 30.31%
Literature References: Nicotinamide derivative; exhibits dual mechanism of action as both nitrovasodilator and potassium channel activator. Prepn: H. Nagano
et al., DE 2714713;
eidem, US 4200640 (1977, 1980 both to Chugai). Pharmacology: N. Taira
et al., Clin. Exp. Pharmacol. Physiol. 6, 301 (1979). Mechanism of action: F. Yoneyama
et al., Cardiovasc. Drugs Ther. 4, 1119 (1990). Symposia on pharmacology and clinical efficacy:
Am. J. Cardiol. 63, Suppl, 1J-85J (1989);
J. Cardiovasc. Pharmacol. 20, Suppl. 3, S1-S108 (1992). Review of clinical potential in ischemic heart disease: H. Purcell, K. Fox,
Br. J. Clin. Pract. 47, 150-154 (1993). Clinical prevention of coronary events in patients with angina: IONA Study Group,
Lancet 359, 1269 (2002).
Properties: Colorless needles from ether/ethanol, mp 92-93°. LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano).
Melting point: mp 92-93°
Toxicity data: LD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)
Therap-Cat: Antianginal.
Keywords: Antianginal; Potassium Channel Activator/Opener.
