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CAS No 65002-17-7 , (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid

  • Name: (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid
  • Synonyms: Thiobutarit;Tiobutarit; Rimatil; DSSTox_CID_28513; CHEMBL80830; De-019;(2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid; N-(2-MERCAPTO-2-METHYL-1-OXOPROPYL)-; L-CYSTEINE; 65002-17-7;
  • CAS Registry Number:
  • Density: 1.289 g/cm3
  • Refractive index: 1.552
  • Safety Statements: Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx. An anti-rheumatic agent. See also MERCAPTANS.
  • Molecular Weight: 223.31302
  • InchiKey: VUAFHZCUKUDDBC-BYPYZUCNSA-N
  • InChI: InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,
    (H,8,11)(H,9,10)/t4-/m0/s1
  • Molecular Formula: C7H13NO3S2
  • Molecular Structure:CAS No:65002-17-7 (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid
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65002-17-7 Bucillamine

  • Bucillamine Rimatil
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
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  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,China
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65002-17-7 Bucillamine

  • Bucillamine Rimatil
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
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  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,China
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65002-17-7 Bucillamine

  • Bucillamine
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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65002-17-7 Bucillamine

  • Bucillamine
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
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  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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65002-17-7 bucillamine

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
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  • Address: 1-102,No.11,Dongjiaominxiang Alley,
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    Beijing 100005,China ,China
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65002-17-7 Bucillamine

  • Bucillamine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
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  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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65002-17-7 Bucillamine

  • Bucillamine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
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  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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65002-17-7 Bucillamine

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65002-17-7 bucillamine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
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  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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65002-17-7 bucillamine

  • China Boronsyn Co.,Ltd [Manufacturer]
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  • Address: 1213 JunMin Road,Pudong,China ,China
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References of (2R)-2-[(2-methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid
Title: Bucillamine
CAS Registry Number: 65002-17-7
CAS Name: N-(2-Mercapto-2-methyl-1-oxopropyl)-L-cysteine
Synonyms: N-(2-mercapto-2-methylpropanoyl)-L-cysteine; N-(2-mercaptoisobutyryl)-L-cysteine; tiobutarit; thiobutarit
Manufacturers' Codes: DE-019; SA-96
Trademarks: Rimatil (Santen)
Molecular Formula: C7H13NO3S2
Molecular Weight: 223.31
Percent Composition: C 37.65%, H 5.87%, N 6.27%, O 21.49%, S 28.72%
Literature References: Disease modifying antirheumatic drug (DMARD) which modulates the immune response; structurally related to tiopronin, q.v. Prepn: T. Fujita et al., DE 2709820; eidem, US 4305958 (1977, 1981 both to Santen); M. Oya et al., Chem. Pharm. Bull. 29, 940 (1981). GC-MS determn in blood: K. Matsuura et al., J. Mass Spectrom. Soc. Jpn. 46, 25 (1998). Clinical immunopharmacology: H. Matsuno et al., Drugs Exp. Clin. Res. 19, 205 (1993). Clinical trials in rheumatoid arthritis: M. Yasuda et al., Clin. Rheumatol. 13, 446 (1994); H. A. Kim, Y. W. Song, Rheumatol. Int. 17, 5 (1997).
Properties: Crystals from ethyl acetate, mp 139-140°. [a]D25 +32.3° (c = 1.0 in ethanol). LD50 in mice (mg/kg): 2285 i.p.; 989.6 i.v. (Fujita, 1981).
Melting point: mp 139-140°
Optical Rotation: [a]D25 +32.3° (c = 1.0 in ethanol)
Toxicity data: LD50 in mice (mg/kg): 2285 i.p.; 989.6 i.v. (Fujita, 1981)
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic; Immunomodulator.