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CAS No 61413-54-5 , 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one

  • Name: 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
  • Synonyms: ZK 62711;Rolipramum [Latin]; 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; Adeo;4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one; ZK-62711; 61413-54-5;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 127-133 °C
  • Density: 1.155 g/cm3
  • Refractive index: 1.552
  • Water Solubility: H2O: 0.2 mg/mL
  • Safety Statements: 26-36
  • Hazard Symbols: Xi
  • EINECS: 262-771-1
  • Molecular Weight: 275.34284
  • InchiKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-
    2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
  • Risk Statements: 36/37/38
  • Molecular Formula: C16H21NO3
  • Molecular Structure:CAS No:61413-54-5 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
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61413-54-5 ROLIPRAM

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany ,Germany
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61413-54-5 ROLIPRAM

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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61413-54-5 ROLIPRAM

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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61413-54-5 ROLIPRAM

  • United States Cayman Chemical Company [Manufacturer]
  • Tel: 734-975-3939; 734-975-3897 (Sales)/ 800-364-9897 (Customer Service)
  • Address: 1180 E.Ellsworth Rd.
    Ann Arbor, MI 48197
    800-364-9897 ,United States
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61413-54-5 6000 ROLIPRAM

  • Germany ABX advanced biochemical compounds GmbH [Manufacturer]
  • Tel: + 49 / 35 28 / 40 41 60
  • Fax: + 49 / 35 28 / 40 41 65
  • Address: ABX advanced biochemical compounds GmbH
    Heinrich-Glaeser-Strasse 10 - 14
    D - 01454 Radeberg, Germany ,Germany
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61413-54-5 ROLIPRAM

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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61413-54-5 Rolipram

  • China LegendChem Technology Co., Ltd. [Manufacturers]
  • Tel: 0575-86558717
  • Fax: legendchem@gmail.com
  • Address: ShaoXing E&T Development Zone, ShaoXing,ZhejiangChina
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61413-54-5 ROLIPRAM

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Title: Rolipram
CAS Registry Number: 61413-54-5
CAS Name: 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
Manufacturers' Codes: ZK-62711
Molecular Formula: C16H21NO3
Molecular Weight: 275.34
Percent Composition: C 69.79%, H 7.69%, N 5.09%, O 17.43%
Literature References: Prototypical selective phosphodiesterase 4 (PDE4) inhibitor. Prepn: BE 826923; R. Schmiechen et al., US 4193926 (1975, 1980 both to Schering AG). Selective enzyme inhibition and enhancement of cAMP accumulation in rat brain tissue: U. Schwabe et al., Mol. Pharmacol. 12, 900 (1976). Antidepressant mechanism of action study: H. Wachtel, Neuropharmacology 22, 267 (1983). Receptor binding study: H. H. Schneider et al., Eur. J. Pharmacol. 127, 105 (1986). Pharmacokinetics: W. Krause, G. Kühne, Xenobiotica 18, 561 (1988). Clinical evaluation in severe depression: F. Eckmann et al., Curr. Ther. Res. 43, 291 (1988). Pharmacology and efficacy in exptl autoimmune encephalomyelitis: N. Sommer et al., Nat. Med. 1, 244 (1995).
Properties: Crystals from ethyl acetate, mp 132°.
Melting point: mp 132°
Use: Pharmacological tool for characterization of phosphodiesterase isoenzymes.
Therap-Cat: Antidepressant.